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Long-Term Nitrogen Dioxide Exposure as a Possible 5-Year Mortality Risk Factor in Diabetic Patients Treated Using Off-Pump Surgical Revascularization-A Retrospective Analysis.
Urbanowicz, Tomasz; Skotak, Krzysztof; Krasinska-Plachta, Aleksandra; Kowalewski, Mariusz; Olasinska-Wisniewska, Anna; Szczepanski, Krystian; Tykarski, Andrzej; Krasinska, Beata; Krasinski, Zbigniew; Jemielity, Marek.
Afiliación
  • Urbanowicz T; Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
  • Skotak K; Thoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, 85-094 Bydgoszcz, Poland.
  • Krasinska-Plachta A; Institute of Environmental Protection-National Research Institute, 02-170 Warsaw, Poland.
  • Kowalewski M; Department of Ophthalmology, Poznan University of Medical Sciences, 60-569 Poznan, Poland.
  • Olasinska-Wisniewska A; Thoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, 85-094 Bydgoszcz, Poland.
  • Szczepanski K; Department of Cardiac Surgery and Transplantology, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.
  • Tykarski A; Cardio-Thoracic Surgery Department, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Centre Maastricht (CARIM), 6229 HX Maastricht, The Netherlands.
  • Krasinska B; Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
  • Krasinski Z; Institute of Environmental Protection-National Research Institute, 02-170 Warsaw, Poland.
  • Jemielity M; Department of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Medicina (Kaunas) ; 60(8)2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39202607
ABSTRACT

Background:

There is mounting evidence that diabetic-related cardiac metabolism abnormalities with oxidative stress and inflammatory mechanism activation align with the functional impairments that result in atherosclerotic lesion formation. Among the possible non-traditional coronary lesion risk factors, environmental exposure may be significant, especially in diabetic patients.

Methods:

A total of 140 diabetic patients (115 (82%) males and 25 (18%) females) with a mean age of 65 (60-71) underwent surgical revascularization due to multivessel coronary disease. The possible all-cause mortality risk factors, including demographical and clinical factors followed by chronic air pollution exposure, were identified.

Results:

All patients were operated on using the off-pump technique and followed for 5.6 (5-6.1) years. The multivariable model for 5-year mortality prediction presented the nitrogen dioxide chronic exposure (HR 3.99, 95% CI 1.16-13.71, p = 0.028) and completeness of revascularization (HR 0.19, 95% CI 0.04-0.86, p = 0.031) as significant all-cause mortality risk factors.

Conclusions:

Ambient air pollutants such as an excessive chronic nitrogen dioxide concentration (>15 µg/m3) may increase 5-year all-cause mortality in diabetic patients following surgical revascularization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dióxido de Nitrógeno Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dióxido de Nitrógeno Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza