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The Effect of Diagnostic and Therapeutic Changes on the Survival of Hodgkin's Lymphoma Patients (1980-2019).
Illés, Árpád; Dobó, Boglárka; Borics, Fanni; Tóthfalusi, Dávid; Pinczés, László Imre; Miltényi, Zsófia.
Afiliación
  • Illés Á; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Dobó B; Doctoral School of Clinical Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Borics F; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Tóthfalusi D; Doctoral School of Clinical Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Pinczés LI; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Miltényi Z; Doctoral School of Clinical Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Medicina (Kaunas) ; 60(8)2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39202553
ABSTRACT
Background and

Objectives:

The overall- and progression-free survival rates of Hodgkin's lymphoma patients have improved. Our goal was to examine the changes in our treatment results and their causes depending on the daily diagnostic and therapeutic practice. Materials and

Methods:

We analysed data of 776 classical Hodgkin lymphoma patients treated between 1980 and 2019. Patient data were investigated in ten-year periods (first period 1980-1989, second period 1990-1999, third period 2000-2009, and fourth period 2010-2019).

Results:

Radiotherapy alone as a first-line treatment was used progressively less often, and in the 4th period it was no longer used before or without chemotherapy. The use of combined chemo- and radiotherapy decreased in the last period, and the number of those patients who received only chemotherapy increased significantly. The 10-year overall survival improved significantly from 1990 to 1999 compared to 2010 to 2019 (74.9% vs. 86.9%). About 30% of patients relapsed after or were refractory to first-line therapy in each period. The incidence of relapse in the last period did not increase after two years, but there was no significant difference between the periods.

Conclusions:

Overall survival rates of HL patients have improved significantly in recent decades, which is due to improved diagnostic methods and modern therapies. Progression-free survival is unchanged; one-third of patients relapse or are refractory to first-line treatment within the first two years. Early recognition of R/R patients, the early application of newer and already available innovative therapies, and the finding of additional new and effective therapies are of particular importance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza