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Impact of Long-Term Pyriproxyfen Exposure on the Genetic Structure and Diversity of Aedes aegypti and Aedes albopictus in Manaus, Amazonas, Brazil.
Leles, Lorena Ferreira de Oliveira; Alvarez, Marcus Vinícius Niz; Cortes, Jose Joaquin Carvajal; Alonso, Diego Peres; Ribolla, Paulo Eduardo Martins; Luz, Sérgio Luiz Bessa.
Afiliación
  • Leles LFO; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane-Fiocruz Amazônia, Manaus 69027-070, Brazil.
  • Alvarez MVN; Programa de Pós-Graduação em Biologia Parasitária, Instituto Oswaldo Cruz (IOC), Rio de Janeiro 21040-900, Brazil.
  • Cortes JJC; Laboratório de Pesquisa em Análises Genéticas, Instituto de Biotecnologia e Biociências, Universidade do Estado de São Paulo (UNESP), Botucatu 18607-440, Brazil.
  • Alonso DP; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane-Fiocruz Amazônia, Manaus 69027-070, Brazil.
  • Ribolla PEM; Laboratório de Pesquisa em Análises Genéticas, Instituto de Biotecnologia e Biociências, Universidade do Estado de São Paulo (UNESP), Botucatu 18607-440, Brazil.
  • Luz SLB; Laboratório de Pesquisa em Análises Genéticas, Instituto de Biotecnologia e Biociências, Universidade do Estado de São Paulo (UNESP), Botucatu 18607-440, Brazil.
Genes (Basel) ; 15(8)2024 Aug 08.
Article en En | MEDLINE | ID: mdl-39202406
ABSTRACT
Aedes aegypti and Aedes albopictus are responsible for transmitting major human arboviruses such as Dengue, Zika, and Chikungunya, posing a global threat to public health. The lack of etiological treatments and efficient vaccines makes vector control strategies essential for reducing vector population density and interrupting the pathogen transmission cycle. This study evaluated the impact of long-term pyriproxyfen exposure on the genetic structure and diversity of Ae. aegypti and Ae. albopictus mosquito populations. The study was conducted in Manaus, Amazonas, Brazil, where pyriproxyfen dissemination stations have been monitored since 2014 up to the present day. Double digest restriction-site associated DNA sequencing was performed, revealing that despite significant local population reductions by dissemination stations with pyriproxyfen in various locations in Brazil, focal intervention has no significant impact on the population stratification of these vectors in urban scenarios. The genetic structuring level of Ae. aegypti suggests it is more stratified and directly affected by pyriproxyfen intervention, while for Ae. albopictus exhibits a more homogeneous and less structured population. The results suggest that although slight differences are observed among mosquito subpopulations, intervention focused on neighborhoods in a capital city is not efficient in terms of genetic structuring, indicating that larger-scale pyriproxyfen interventions should be considered for more effective urban mosquito control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Aedes / Mosquitos Vectores Límite: Animals / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Genes (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Aedes / Mosquitos Vectores Límite: Animals / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Genes (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza