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Prenatal Diagnosis of Cleft Lip and Palate: A Retrospective Study.
Braila, Anca Daniela; Damian, Constantin Marian; Albu, Cristina-Crenguta; Botoaca, Oana; Dȋra, Laurențiu Mihai; Albu, Stefan-Dimitrie; Braila, Matei Georgian; Banațeanu, Andreea-Mariana; Poalelungi, Cristian-Viorel; Bogdan-Andreescu, Claudia Florina.
Afiliación
  • Braila AD; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  • Damian CM; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  • Albu CC; Department of Genetics, Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Botoaca O; Department of Speciality Disciplines, Faculty of Dental Medicine, "Titu Maiorescu" University, 031593 Bucharest, Romania.
  • Dȋra LM; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  • Albu SD; Department of Periodontology, Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Braila MG; Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Banațeanu AM; Department of Speciality Disciplines, Faculty of Dental Medicine, "Titu Maiorescu" University, 031593 Bucharest, Romania.
  • Poalelungi CV; Department of Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Bogdan-Andreescu CF; Department of Speciality Disciplines, Faculty of Dental Medicine, "Titu Maiorescu" University, 031593 Bucharest, Romania.
J Clin Med ; 13(16)2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39200946
ABSTRACT
Cleft lip and/or palate are prevalent congenital anomalies. Early and accurate diagnosis allows proper case management. The

Objective:

This retrospective cohort study aimed to investigate the association between cleft lip and palate and other congenital anomalies.

Methods:

This study analyzed 17 pregnancies prenatally diagnosed with cleft lip and palate. The investigations consisted of ultrasound examination, fetal karyotyping through amniocentesis, and family tree analysis. In the presence of an abnormal fetal karyotype, the parental karyotype was also indicated.

Results:

Of the 17 cases identified, 9 (52.94%) were syndromic and 8 (47.06%) were non-syndromic. The genetic syndromes identified in association with cleft lip and palate in this study included translocation syndrome (one case), Patau syndrome, trisomy 13 (seven cases), and Edwards syndrome, mosaic trisomy 18 (one case).

Conclusions:

A comprehensive approach ensures a thorough assessment and accurate diagnosis. Early detection and a multidisciplinary approach allow appropriate case management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza