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[15O]H2O PET/MRI for Assessment of Complete Response to Neoadjuvant or Induction Chemotherapy in Patients with Muscle-Invasive Bladder Cancer: A Pilot Study.
Körner, Stefanie Korsgaard; Tolbod, Lars Poulsen; Pedersen, Bodil G; Boellaard, Thierry; Milling, Rikke Vilsbøll; Brandt, Simone Buchardt; Agerbæk, Mads; Dyrskjøt, Lars; Bouchelouche, Kirsten; Jensen, Jørgen B.
Afiliación
  • Körner SK; Department of Urology, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Tolbod LP; Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Pedersen BG; Department of Radiology, Regional Hospital Horsens, 8700 Horsens, Denmark.
  • Boellaard T; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Milling RV; Department of Radiology, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Brandt SB; Department of Radiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.
  • Agerbæk M; Department of Urology, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Dyrskjøt L; Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Bouchelouche K; Department of Urology, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Jensen JB; Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.
J Clin Med ; 13(16)2024 Aug 08.
Article en En | MEDLINE | ID: mdl-39200797
ABSTRACT

Background:

Accurate assessment of therapy response to chemotherapy could possibly offer a bladder-sparing approach in selected patients with localized muscle-invasive bladder cancer (MIBC). The aim of this study was to evaluate whether [15O]H2O PET/MRI can be used for assessment of complete local pathological response to preoperative chemotherapy in patients with MIBC.

Methods:

This prospective pilot study included 13 patients with MIBC treated with neoadjuvant or induction chemotherapy and subsequent radical cystectomy. Patients underwent a [15O]H2O PET/MRI scan before chemotherapy and another scan after chemotherapy before radical cystectomy. Volumes of interest were delineated on T2-weighted MRI and transferred to parametric images for dynamic analysis. Tumor blood flow (TBF) was estimated by [15O]H2O PET. Changes in TBF were compared with histopathology. The Wilcoxon matched-pairs signed-ranks test was used for comparing pre- and post-chemotherapy measurements.

Results:

Mean TBF decreased by 49%. Mean TBF in complete responders (ypT0N0/ypTis) was not significantly different from non-complete responders (≥ypT1) (p = 0.52).

Conclusions:

Despite a measurable decrease in TBF after chemotherapy treatment, we were not able to estimate a TBF threshold for identifying complete responders to chemotherapy for MIBC patients. Further studies are needed to elucidate the potential of [15O]H2O PET/MRI in assessing therapy response in MIBC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza