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Basal Linear Deposit: Normal Physiological Ageing or a Defining Lesion of Age-Related Macular Degeneration?
Thananjeyan, Akshaya Lakshmi; Arnold, Jennifer; Lee, Mitchell; Au, Cheryl; Pye, Victoria; Madigan, Michele C; Cherepanoff, Svetlana.
Afiliación
  • Thananjeyan AL; St. Vincent's Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia.
  • Arnold J; School of Medicine, University of Sydney, Camperdown, NSW 2006, Australia.
  • Lee M; Marsden Eye Specialists, Parramatta, NSW 2150, Australia.
  • Au C; School of Clinical Medicine, University of NSW, Sydney, NSW 2052, Australia.
  • Pye V; Anatomical Pathology, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
  • Madigan MC; Anatomical Pathology, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
  • Cherepanoff S; School of Medicine, University of Notre Dame, Sydney, NSW 2008, Australia.
J Clin Med ; 13(16)2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39200753
ABSTRACT

Objective:

To determine if basal linear deposit (BLinD) is a specific lesion of age-related macular degeneration (AMD).

Methods:

The cohort was selected from a clinically and histopathologically validated archive (Sarks Archive) and consisted of 10 normal eyes (age 55-80 years) without any macular basal laminar deposit (BLamD) (Sarks Group I) and 16 normal aged eyes (age 57-88 years) with patchy BLamD (Sarks Group II). Only eyes with in vivo fundus assessment and corresponding high-resolution transmission electron microscopy (TEM) micrographs of the macula were included. Semithin sections and fellow-eye paraffin sections were additionally examined. BLinD was defined as a diffuse layer of electron-lucent vesicles external to the retinal pigment epithelium (RPE) basement membrane by TEM and was graded as follows (i) Grade 0, absence of a continuous layer; (ii) Grade 1, a continuous layer up to three times the thickness of the RPE basement membrane (0.9 µm); (iii) Grade 2, a continuous layer greater than 0.9 µm. Bruch's membrane (BrM) hyalinisation and RPE abnormalities were determined by light microscopic examination of corresponding semithin and paraffin sections.

Results:

BLinD was identified in both normal (30%) and normal aged (62.5%) eyes. BLinD was thicker in normal aged eyes (p = 0.045; 95% CI 0.04-3.4). BLinD thickness positively correlated with both the degree of BrM hyalinisation (p = 0.049; 95% CI 0.05-2.69) and increasing microscopic RPE abnormalities (p = 0.022; 95% CI 0.188-2.422). RPE abnormalities were more likely to be observed in eyes with increased BrM hyalinisation (p = 0.044; 95% CI 0.61-4.319).

Conclusions:

BLinD is most likely an age-related deposit rather than a specific lesion of AMD. Its accumulation is associated with increasing BrM hyalinisation and microscopic RPE abnormalities, suggesting a relationship with dysregulated RPE metabolism and/or transport.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza