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Combined Peptidomics and Metabolomics Analyses to Characterize the Digestion Properties and Activity of Stropharia rugosoannulata Protein-Peptide-Based Materials.
Li, Wen; Chen, Wanchao; Zhang, Zhong; Wu, Di; Liu, Peng; Li, Zhengpeng; Yang, Yan.
Afiliación
  • Li W; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
  • Chen W; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
  • Zhang Z; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
  • Wu D; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
  • Liu P; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
  • Li Z; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
  • Yang Y; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
Foods ; 13(16)2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39200473
ABSTRACT
Protein-peptide-based materials typically possess high nutritional value and various physiological regulatory activities. This study evaluated the digestion, metabolism, and activity of Stropharia rugosoannulata protein-peptide-based materials. After the S. rugosoannulata protein-peptide-based materials were digested (simulated) orally, in the stomach, and in the intestines, the proportions of >10,000 Da, 5000~10,000 Da, and <180 Da in the digestion products increased, and the peptide content was maintained at more than 120 mg/g dry weight. The digestion products of eight test groups with different oral-gastrointestinal digestion-level settings all had suitable ACE inhibitory activity (IC50 range 0.004~0.096 mg/mL). The main metabolite groups were lipid-like molecules, fatty acids, carboxylic acids, their derivatives, amino acids, peptides, and analogs. Bile and glycosylated amino acids were the main compounds that caused differences between groups. KEGG pathways enriched in differentially expressed metabolites included eight significantly upregulated pathways, including valine, leucine, and isoleucine biosynthesis, etc., and six significantly downregulated pathways, including the citric acid cycle (tricarboxylic acid cycle), etc. The arginine and proline metabolism pathways and the aminoacyl-tRNA biosynthesis pathways were upregulation and downregulation pathways that enriched multiple differentially expressed metabolites. Twenty-six metabolites, including bile acids, total bile acids, and the essential amino acids L-isoleucine and L-leucine, were differentially expressed metabolite markers of the protein-peptide-based material oral-gastrointestinal digestion products.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Foods Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Foods Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza