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Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases.
Issa, Shaza; Fayoud, Haidar; Shaimardanova, Alisa; Sufianov, Albert; Sufianova, Galina; Solovyeva, Valeriya; Rizvanov, Albert.
Afiliación
  • Issa S; Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia.
  • Fayoud H; Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia.
  • Shaimardanova A; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
  • Sufianov A; Department of Neurosurgery, Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Russia.
  • Sufianova G; The Research and Educational Institute of Neurosurgery, Peoples' Friendship University of Russia (RUDN), 117198 Moscow, Russia.
  • Solovyeva V; Department of Pharmacology, Tyumen State Medical University, 625023 Tyumen, Russia.
  • Rizvanov A; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Biomedicines ; 12(8)2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39200370
ABSTRACT
Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza