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Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients.
Bucurica, Sandica; Nancoff, Andreea Simona; Dutu, Madalina; Mititelu, Mihaela Raluca; Gaman, Laura Elena; Ionița-Radu, Florentina; Jinga, Mariana; Maniu, Ionela; Ruța, Florina.
Afiliación
  • Bucurica S; Department Gastroenterology, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.
  • Nancoff AS; Department of Gastroenterology, University Emergency Central Military Hospital, 010825 Bucharest, Romania.
  • Dutu M; Department of Gastroenterology, University Emergency Central Military Hospital, 010825 Bucharest, Romania.
  • Mititelu MR; Department of Anesthesiology and Intensive Care, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.
  • Gaman LE; Department of Anesthesiology and Intensive Care, Dr. Carol Davila Central Military Emergency University Hospital, 010242 Bucharest, Romania.
  • Ionița-Radu F; Department of Nuclear Medicine, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.
  • Jinga M; Department of Nuclear Medicine, University Emergency Central Military Hospital, 010825 Bucharest, Romania.
  • Maniu I; Department of Biochemistry, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.
  • Ruța F; Department Gastroenterology, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.
Biomedicines ; 12(8)2024 Jul 29.
Article en En | MEDLINE | ID: mdl-39200151
ABSTRACT
Anomalies in lipid metabolism involve multifactorial pathogenesis, among other factors, being associated with an inflammatory state and disturbances in vitamin D status. The literature has focused on the binary relationships between inflammation and dyslipidemia, vitamin D and dyslipidemia, or vitamin D and inflammation. Our study aimed to explore the link between all these three factors 25-OH vitamin D serum levels, the presence of inflammation assessed through serum C-reactive protein (CRP), and serum lipid profile in 2747 hospitalized patients. Our results showed a positive correlation of HDL-C with 25 (OH) vitamin D and a negative correlation of HDL-C with CRP. This relationship had different patterns in the statistical network analysis. The network analysis patterns are preserved for males and females, except for the relationship between CRP and vitamin D, which is present in male cases and absent in females. The same triangular relationship between all three-CRP, vitamin D, and HDL-C was found with different strengths of partial correlation in obese and non-obese patients. This pattern was similar in patients with and without fatty liver. A shifted pattern was found in the network analysis of hypertensive patients. The CRP was negatively correlated with vitamin D and HDL-C, and vitamin D was positively correlated with HDL-C in non-hypertensive patients. Castelli's Risk indexes I and II were positively associated with CRP, suggesting that increased cardiovascular risk is proportional to an inflammatory state. The triad formed by altered serum lipid levels, inflammation, and vitamin D represents a complex relationship marked by specific dynamics between lipidic fractions such as HDL-C and C-reactive protein and vitamin D.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza