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Pathological Features Associated with Lymph Node Disease in Patients with Appendiceal Neuroendocrine Tumors.
Rodriguez Franco, Salvador; Ghaffar, Sumaya Abdul; Jin, Ying; Weiss, Reed; Hamermesh, Mona; Khomiak, Andrii; Sugawara, Toshitaka; Franklin, Oskar; Leal, Alexis D; Lieu, Christopher H; Schulick, Richard D; Del Chiaro, Marco; Ahrendt, Steven; McCarter, Martin D; Gleisner, Ana L.
Afiliación
  • Rodriguez Franco S; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Ghaffar SA; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Jin Y; Department of Biostatistics and Informatics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Weiss R; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Hamermesh M; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Khomiak A; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Sugawara T; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Franklin O; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Leal AD; Division of Medical Oncology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Lieu CH; Cancer Center, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Schulick RD; Division of Medical Oncology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Del Chiaro M; Cancer Center, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Ahrendt S; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • McCarter MD; Cancer Center, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Gleisner AL; Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Cancers (Basel) ; 16(16)2024 Aug 22.
Article en En | MEDLINE | ID: mdl-39199692
ABSTRACT
This study aimed to evaluate the role of pathological features beyond tumor size in the risk of lymph node metastasis in appendiceal neuroendocrine tumors. Analyzing data from the national cancer database, we found that among 5353 cases, 18.8% had lymph node metastasis. Focusing on tumors smaller than 2 cm, a subject of considerable debate in treatment strategies, we identified lymphovascular invasion as one of the strongest predictors of lymph node disease. Interestingly, extension into the subserosa and beyond, a current factor in the staging system, was not a strong predictor. These findings suggest that careful interpretation of pathological features is needed when selecting therapeutic approaches using current staging systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza