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Long-Term Outcomes of Childhood Acute Lymphocytic Leukemia Treated with Adapted Berlin-Frankfurt-Münster (BFM) Protocols: A Multicentric Analysis from a Developing Country.
Horn, Patricia Regina Cavalcanti Barbosa; Ribeiro-Carvalho, Marilza de Moura; Azevedo, Alice Maria Boulhosa de; Sousa, Adriana Martins de; Faria, Simone; Wiggers, Cristina; Rouxinol, Soraia; Schramm, Marcia Trindade; Sanches, Bárbara Sarni; Duarte, Nathalia Lopez; Seixas, Teresa de Souza Fernandez; Gomes, Bernadete Evangelho; Oliveira, Elen de; Arcuri, Leonardo Javier; Costa, Elaine Sobral da; Land, Marcelo Gerardin Poirot; Souza, Maria Helena Faria Ornellas de.
Afiliación
  • Horn PRCB; Department of Hematology, Universidade Estadual do Rio de Janeiro, Rio de Janeiro 20559-900, Brazil.
  • Ribeiro-Carvalho MM; Bone Marrow Transplantation Unit, Instituto Nacional de Cancer, Rio de Janeiro 20230-130, Brazil.
  • Azevedo AMB; Department of Hematology, Universidade Estadual do Rio de Janeiro, Rio de Janeiro 20559-900, Brazil.
  • Sousa AM; Pediatric Hematolgy Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Faria S; Pediatric Hematolgy Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Wiggers C; Department of Hematology, Universidade Estadual do Rio de Janeiro, Rio de Janeiro 20559-900, Brazil.
  • Rouxinol S; Department of Hematology, Universidade Estadual do Rio de Janeiro, Rio de Janeiro 20559-900, Brazil.
  • Schramm MT; Pediatric Hematology Department, Hospital Federal da Lagoa, Rio de Janeiro 22470-050, Brazil.
  • Sanches BS; Hematology Department, Instituto Nacional de Cancer, Rio de Janeiro 20230-130, Brazil.
  • Duarte NL; Pediatric Hematolgy Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Seixas TSF; National Institute of Science and Technology in Childhood Cancer Biology and Pediatric Oncology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-150, Brazil.
  • Gomes BE; Pediatric Hematolgy Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Oliveira E; Bone Marrow Transplantation Unit, Instituto Nacional de Cancer, Rio de Janeiro 20230-130, Brazil.
  • Arcuri LJ; Bone Marrow Transplantation Unit, Instituto Nacional de Cancer, Rio de Janeiro 20230-130, Brazil.
  • Costa ESD; Pediatric Hematolgy Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
  • Land MGP; Bone Marrow Transplantation Unit, Instituto Nacional de Cancer, Rio de Janeiro 20230-130, Brazil.
  • Souza MHFO; Hospital Israelita Albert Einstein, Academic Research Organization, São Paulo 01305-000, Brazil.
Cancers (Basel) ; 16(16)2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39199668
ABSTRACT

INTRODUCTION:

The objective of the current study was to determine the survival probabilities of children and adolescents with acute lymphocytic leukemia treated with adapted Berlin-Frankfurt-Münster (BFM) protocols and compare our results with the original BFM reports.

METHODS:

This retrospective study included 695 patients up to 19 years old treated with adapted BFM protocols between 1997 and 2018 in four hospitals in Rio de Janeiro. The 1997-2007 and 2008-2018 cohorts were analyzed separately.

RESULTS:

More than half of the patients were stratified into the high-risk BFM classification. Overall and event-free survivals were, in the 1997-2007 period, respectively, 88% and 80% (BFM standard risk group-SRG), 75% and 67% (intermediate risk group-IRG), and 48% and 33% (high-risk group-HRG). The corresponding numbers for the 2008-2018 period were 93% and 84% (SRG), 75% and 63% (IRG), and 64% and 57% (HRG). In the second period, both the OS (HR = 0.71, p = 0.011) and EFS (HR = 0.62, p < 0.001) were higher. Except for the intermediate-risk group, the latter results are comparable to the BFM.

CONCLUSION:

The BFM protocol adaptations can be safely implemented in developing countries, accounting for local specificities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza