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Alzheimer's Disease Related Biomarkers Were Associated with Amnestic Cognitive Impairment in Parkinson's Disease: A Cross-Sectional Cohort Study.
Xue, Xiaofan; Mei, Shanshan; Huang, Anqi; Wu, Zhiyue; Zeng, Jingrong; Song, Haixia; An, Jing; Zhang, Lijuan; Liu, Guozhen; Zhou, Lichun; Cai, Yanning; Xu, Baolei; Xu, Erhe; Chan, Piu.
Afiliación
  • Xue X; Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Mei S; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China.
  • Huang A; Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Wu Z; Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Zeng J; Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Song H; Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • An J; Department of Neurology, The People's Hospital of Shijiazhuang, Shijiazhuang 050000, China.
  • Zhang L; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Liu G; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Zhou L; Parkinson's Disease Cloud Medical Technology Company, Beijing 100055, China.
  • Cai Y; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China.
  • Xu B; Department of Clinical Biobank and Central Laboratory, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Xu E; Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
  • Chan P; Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Brain Sci ; 14(8)2024 Aug 02.
Article en En | MEDLINE | ID: mdl-39199480
ABSTRACT

BACKGROUND:

Cognitive impairment is common in patients with Parkinson's disease (PD) and occurs through multiple mechanisms, including Alzheimer's disease (AD) pathology and the involvement of α-synucleinopathies. We aimed to investigate the pathological biomarkers of both PD and AD in plasma and neuronal extracellular vesicles (EVs) and their association with different types of cognitive impairment in PD patients.

METHODS:

A total of 122 patients with PD and 30 healthy controls were included in this cross-sectional cohort study between March 2021 and July 2023. Non-dementia PD patients were divided into amnestic and non-amnestic groups according to the memory domain of a neuropsychological assessment. Plasma and neuronal EV biomarkers, including α-synuclein (α-syn), beta-amyloid (Aß), total tau (T-tau), phosphorylated tau181 (p-tau181), and glial fibrillary acidic protein (GFAP), were measured using a single-molecule array and a chemiluminescence immunoassay, respectively.

RESULTS:

Neuronal EV but not plasma α-syn levels, were significantly increased in PD as compared to healthy controls, and they were positively associated with UPDRS part III scores and the severity of cognitive impairment. A lower plasma Aß42 level and higher neuronal EV T-tau level were found in the amnestic PD group compared to the non-amnestic PD group.

CONCLUSIONS:

The results of the current study demonstrate that neuronal EV α-syn levels can be a sensitive biomarker for assisting in the diagnosis and disease severity prediction of PD. Both AD and PD pathologies are important factors in cognitive impairment associated with PD, and AD pathologies are more involved in amnestic memory deficit in PD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza