The Role of Inositols in Endocrine and Neuroendocrine Tumors.

Mormando, Marilda; Puliani, Giulia; Bianchini, Marta; Lauretta, Rosa; Appetecchia, Marialuisa

Mormando, Marilda; Puliani, Giulia; Bianchini, Marta; Lauretta, Rosa; Appetecchia, Marialuisa.

Afiliación

Mormando M; Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Puliani G; Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Bianchini M; Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Lauretta R; Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Appetecchia M; Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.

Biomolecules ; 14(8)2024 Aug 14.

Article en En | MEDLINE | ID: mdl-39199391

ABSTRACT

ABSTRACT

Inositols have demonstrated a role in cancer prevention and treatment in many kinds of neoplasms. Their molecular mechanisms vary from the regulation of survival and proliferative pathways to the modulation of immunity and oxidative stress. The dysregulation of many pathways and mechanisms regulated by inositols has been demonstrated in endocrine and neuroendocrine tumors but the role of inositol supplementation in this context has not been clarified. The aim of this review is to summarize the molecular basis of the possible role of inositols in endocrine and neuroendocrine tumors, proposing it as an adjuvant therapy.

Asunto(s)

Inositol; Tumores Neuroendocrinos; Humanos; Tumores Neuroendocrinos/metabolismo; Tumores Neuroendocrinos/tratamiento farmacológico; Inositol/metabolismo; Inositol/uso terapéutico; Neoplasias de las Glándulas Endocrinas/metabolismo; Neoplasias de las Glándulas Endocrinas/tratamiento farmacológico; Animales; Estrés Oxidativo

Palabras clave

endocrine cancer; inositol hexakisphosphate; inositols; myo-inositols; neuroendocrine neoplasms; thyroid cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tumores Neuroendocrinos / Inositol Límite: Animals / Humans Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza

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