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Burst-Suppression EEG Reactivity to Photic Stimulation-A Translational Biomarker in Hypoxic-Ischemic Brain Injury.
Pâslaru, Alexandru-Catalin; Calin, Alexandru; Morozan, Vlad-Petru; Stancu, Mihai; Tofan, Laurențiu; Panaitescu, Anca Maria; Zagrean, Ana-Maria; Zagrean, Leon; Moldovan, Mihai.
Afiliación
  • Pâslaru AC; Division of Physiology-Neuroscience, Department of Functional Sciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Calin A; Department of Clinical Neurophysiology, King's College Hospital NHS Foundation Trust, London SE59RS, UK.
  • Morozan VP; Division of Physiology-Neuroscience, Department of Functional Sciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Stancu M; Division of Physiology-Neuroscience, Department of Functional Sciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Tofan L; Division of Neurobiology, Ludwig-Maximilian University, 80539 Munich, Germany.
  • Panaitescu AM; Division of Physiology-Neuroscience, Department of Functional Sciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Zagrean AM; Division of Physiology-Neuroscience, Department of Functional Sciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Zagrean L; Clinical Hospital of Obstetrics and Gynaecology Filantropia, 011132 Bucharest, Romania.
  • Moldovan M; Obstetrics and Gynaecology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Biomolecules ; 14(8)2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39199341
ABSTRACT
The reactivity of an electroencephalogram (EEG) to external stimuli is impaired in comatose patients showing burst-suppression (BS) patterns following hypoxic-ischemic brain injury (HIBI). We explored the reactivity of BS induced by isoflurane in rat models of HIBI and controls using intermittent photic stimulation (IPS) delivered to one eye. The relative time spent in suppression referred to as the suppression ratio (SR) was measured on the contralateral fronto-occipital cortical EEG channel. The BS reactivity (BSR) was defined as the decrease in the SR during IPS from the baseline before stimulation (SRPRE). We found that BSR increased with SRPRE. To standardize by anesthetic depth, we derived the BSR index (BSRi) as BSR divided by SRPRE. We found that the BSRi was decreased at 3 days after transient global cerebral ischemia in rats, which is a model of brain injury after cardiac arrest. The BSRi was also reduced 2 months after experimental perinatal asphyxia in rats, a model of birth asphyxia, which is a frequent neonatal complication in humans. Furthermore, Oxytocin attenuated BSRi impairment, consistent with a neuroprotective effect in this model. Our data suggest that the BSRi is a promising translational marker in HIBI which should be considered in future neuroprotection studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Luminosa / Biomarcadores / Hipoxia-Isquemia Encefálica / Electroencefalografía Límite: Animals / Female / Humans / Male Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Luminosa / Biomarcadores / Hipoxia-Isquemia Encefálica / Electroencefalografía Límite: Animals / Female / Humans / Male Idioma: En Revista: Biomolecules Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza