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Synthesis of silver nanoparticles embedded into melamine polyaminal networks as antibacterial and anticancer active agents.
Alotaibi, Maha M; Almalki, Bodoor; Tashkandi, Nada; Basingab, Fatemah; Abdullah, Samaa; Alkayal, Nazeeha S.
Afiliación
  • Alotaibi MM; Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, 21589, Jeddah, Saudi Arabia.
  • Almalki B; Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, 21589, Jeddah, Saudi Arabia.
  • Tashkandi N; Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, 21589, Jeddah, Saudi Arabia.
  • Basingab F; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O Box 80200, 21589, Jeddah, Saudi Arabia.
  • Abdullah S; Immunology Unit, King Fahad Medical Research Centre, King Abdulaziz University, P.O Box 80200, 22252, Jeddah, Saudi Arabia.
  • Alkayal NS; College of Pharmacy, Amman Arab University, Amman, 11953, Jordan.
Sci Rep ; 14(1): 20008, 2024 08 28.
Article en En | MEDLINE | ID: mdl-39198544
ABSTRACT
Silver nanoparticles were successfully incorporated into a melamine-based polymer, resulting in the synthesis of (Ag NPs@Bipy-PAN) through a reverse double solvent approach. The synthesised Ag NPs@Bipy-PAN polymer underwent extensive characterisation through Powder X-ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy and Energy Dispersive X-ray (EDX) and Thermal Gravimetric Analysis. PXRD analysis confirmed the successful encapsulation of Ag nanoparticles and provided insights into the amorphous nature of the polymer following encapsulation. SEM and EDX analyses further corroborated the presence and distribution of Ag nanoparticles on the polymer surface. The biological efficacy of the Ag NPs@Bipy-PAN polymer was evaluated through antibacterial, anti-breast cancer, and biocompatibility assays. The results demonstrated notable antibacterial and anticancer activities, with significant efficacy against bacterial strains and breast cancer cells. Biocompatibility assessments indicated acceptable compatibility, particularly at a concentration of 2.5 mg/mL, compared to untreated control cells. These findings suggest that Ag NPs@Bipy-PAN has considerable potential as a candidate for cancer-targeted and antimicrobial drug delivery systems. The incorporation of silver nanoparticles into the melamine-based polymer enhances the safety profile of these systems in in vivo conditions, making them a viable option for advanced therapeutic applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Triazinas / Nanopartículas del Metal / Antibacterianos / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Triazinas / Nanopartículas del Metal / Antibacterianos / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido