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Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai.
Wang, Gui Fang; Zhang, You Zhi; Yang, Hai Yan; Yang, Yi; Dong, Liang; Zhang, Peng; Liu, Jie; Chen, Xiao Dong; Gong, Yi.
Afiliación
  • Wang GF; Department of Respiratory and Critical Care Medicine, Quzhou People's Hospital, Quzhou 324000, Zhejiang, China.
  • Zhang YZ; Department of Respiratory and Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Yang HY; Centre of Hydrogen Science, Shanghai Jiao Tong University & Key Lab of Hydrogen Science, Shanghai 200240, China.
  • Yang Y; Department of Respiratory and Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Dong L; Department of Respiratory and Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Zhang P; Department of Respiratory and Critical Care Medicine, Shanghai Public Health Clinical Centre, Fudan University, Shanghai 201508, China.
  • Liu J; Centre of Hydrogen Science, Shanghai Jiao Tong University & Key Lab of Hydrogen Science, Shanghai 200240, China.
  • Chen XD; Department of Respiratory and Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Gong Y; Department of Respiratory and Critical Care Medicine, Quzhou People's Hospital, Quzhou 324000, Zhejiang, China;Department of Respiratory and Critical Care Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Biomed Environ Sci ; 37(8): 811-822, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39198247
ABSTRACT

Objective:

Air pollution is a leading public health issue. This study investigated the effect of air quality and pollutants on pulmonary function and inflammation in patients with asthma in Shanghai.

Methods:

The study monitored 27 asthma outpatients for a year, collecting data on weather, patient self-management [daily asthma diary, peak expiratory flow (PEF) monitoring, medication usage], spirometry and serum markers. To explore the potential mechanisms of any effects, asthmatic mice induced by ovalbumin (OVA) were exposed to PM 2.5.

Results:

Statistical and correlational analyses revealed that air pollutants have both acute and chronic effects on asthma. Acute exposure showed a correlation between PEF and levels of ozone (O 3) and nitrogen dioxide (NO 2). Chronic exposure indicated that interleukin-5 (IL-5) and interleukin-13 (IL-13) levels correlated with PM 2.5 and PM 10 concentrations. In asthmatic mouse models, exposure to PM 2.5 increased cytokine levels and worsened lung function. Additionally, PM 2.5 exposure inhibited cell proliferation by blocking the NF-κB and ERK phosphorylation pathways.

Conclusion:

Ambient air pollutants exacerbate asthma by worsening lung function and enhancing Th2-mediated inflammation. Specifically, PM 2.5 significantly contributes to these adverse effects. Further research is needed to elucidate the mechanisms by which PM 2.5 impacts asthma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Contaminantes Atmosféricos / Pulmón Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Contaminantes Atmosféricos / Pulmón Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China