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Continuous Rhythm Monitoring With Implanted Loop Recorders in Children and Adolescents With Brugada Syndrome.
Bergonti, Marco; Ciconte, Giuseppe; Cruzalegui Gomez, Jose; Crotti, Lia; Arbelo, Elena; Casella, Michela; Saenen, Johan; Rossi, Andrea; Pannone, Luigi; Martinez-Barrios, Estefania; Compagnucci, Paolo; Russo, Vincenzo; Berne, Paola; Van Leuven, Olivier; Boccellino, Antonio; Marcon, Lorenzo; Dagradi, Federica; Landra, Federico; Özkartal, Tardu; Comune, Angelo; Conti, Sergio; Ribatti, Valentina; Campuzano, Oscar; Brugada, Pedro; de Asmundis, Carlo; Brugada, Josep; Pappone, Carlo; Tondo, Claudio; Schwartz, Peter J; Auricchio, Angelo; Sarquella-Brugada, Georgia; Conte, Giulio.
Afiliación
  • Bergonti M; Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
  • Ciconte G; Arrhythmology Department, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, Milan, Italy; School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
  • Cruzalegui Gomez J; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Universitat de Barcelona. Barcelona, Spain; Arrítmies Pediàtriques, Cardiologia Genètica i Mort sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugue
  • Crotti L; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, IRCCS, Milan, Italy; Department of Medicine and Surgery, University Milano Bicocca, Milan, Italy.
  • Arbelo E; Arrhythmia Section, Cardiology Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
  • Casella M; Cardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti," Ancona, Italy; Department of Clinical, Special and Dental Sciences, Marche Polytechnic University, Ancona, Italy.
  • Saenen J; Department of Cardiology, University Hospital Antwerp, Edegem, Belgium.
  • Rossi A; Arrhythmology Division, Fondazione Gabriele Monasterio Consiglio Nazionale delle Richerche-Regione Toscana, Pisa, Italy.
  • Pannone L; Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, Brussels, Belgium.
  • Martinez-Barrios E; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Universitat de Barcelona. Barcelona, Spain; Arrítmies Pediàtriques, Cardiologia Genètica i Mort sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugue
  • Compagnucci P; Cardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti," Ancona, Italy; Department of Clinical, Special and Dental Sciences, Marche Polytechnic University, Ancona, Italy.
  • Russo V; Cardiology Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli," Monaldi Hospital, Naples, Italy.
  • Berne P; Department of Cardiology, Ospedale Santissima Annunziata, University of Sassari, Sassari, Italy.
  • Van Leuven O; Department of Cardiology, University Hospital Antwerp, Edegem, Belgium.
  • Boccellino A; Arrhythmology Department, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, Milan, Italy; School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
  • Marcon L; Department of Clinical Electrophysiology and Cardiac Pacing, Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical, Surgery and Dentist Sciences, University of Milan, Milan, Italy.
  • Dagradi F; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, IRCCS, Milan, Italy.
  • Landra F; Arrhythmology Division, Fondazione Gabriele Monasterio Consiglio Nazionale delle Richerche-Regione Toscana, Pisa, Italy.
  • Özkartal T; Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
  • Comune A; Cardiology Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli," Monaldi Hospital, Naples, Italy.
  • Conti S; Department of Cardiac Electrophysiology, Azienda di Rilievo Nazionale ed Alta Specializzazione Ospedali Civico Di Cristina Benfratelli, Palermo, Italy.
  • Ribatti V; Department of Clinical Electrophysiology and Cardiac Pacing, Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical, Surgery and Dentist Sciences, University of Milan, Milan, Italy.
  • Campuzano O; Department of Medical Sciences, Faculty of Medicine, Universitat de Girona, Girona, Spain.
  • Brugada P; Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, Brussels, Belgium.
  • de Asmundis C; Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, Brussels, Belgium.
  • Brugada J; Arrhythmia Section, Cardiology Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
  • Pappone C; Arrhythmology Department, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, Milan, Italy; School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
  • Tondo C; Department of Clinical Electrophysiology and Cardiac Pacing, Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical, Surgery and Dentist Sciences, University of Milan, Milan, Italy.
  • Schwartz PJ; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, IRCCS, Milan, Italy.
  • Auricchio A; Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
  • Sarquella-Brugada G; Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Hospital Sant Joan de Déu, Universitat de Barcelona. Barcelona, Spain; Arrítmies Pediàtriques, Cardiologia Genètica i Mort sobtada, Malalties Cardiovasculars en el Desenvolupament, Institut de Recerca Sant Joan de Déu, Esplugue
  • Conte G; Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland. Electronic address: giulio.conte@eoc.ch.
J Am Coll Cardiol ; 84(10): 921-933, 2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39197982
ABSTRACT

BACKGROUND:

Young (<18 years of age) patients with Brugada syndrome (BrS) are often under-represented in BrS studies and their management, especially related to syncopal episodes, remains unclear.

OBJECTIVES:

This study sought to describe the arrhythmia prevalence among young patients with BrS undergoing continuous rhythm monitoring by implantable loop recorder (ILR) and to assess the etiology behind syncope of undetermined origin.

METHODS:

A total of 147 patients with BrS with ILR were enrolled in 12 international centers and divided into pediatric (age <12 years; n = 77, 52%) and adolescents (age 13-18 years; n = 70, 48%).

RESULTS:

Mean age was 11.3 years, 53 patients (36.1%) were female, and 31 (21.1%) had spontaneous type 1 electrocardiograms. Over a median follow-up of 3.6 years (Q1-Q3 1.6-4.8 years), an arrhythmic event was recorded in 33 patients (22.4%), mainly of nonventricular origin 15 atrial (10.2%) and 16 bradyarrhythmic events (10.9%). Ventricular arrhythmias occurred in 4 patients, all with spontaneous BrS, and were fever-related in one-half. Among all patients with recurrence of syncope during follow-up, true arrhythmic syncope was documented in 5 (17.8%), and it was due to bradyarrhythmias or atrial arrhythmias in 3 cases (60%).

CONCLUSIONS:

Continuous rhythm monitoring with ILRs in young patients with BrS detects a broad range of arrhythmias. Ventricular arrhythmias occur predominantly in patients with spontaneous type 1 electrocardiograms and during fever. Despite the young age, bradyarrhythmias and atrial arrhythmias are frequent and represent the cause of arrhythmic syncope in 60% of patients. Young patients with BrS with syncope of undetermined origin may benefit from ILR implant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electrocardiografía Ambulatoria / Síndrome de Brugada Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Am Coll Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electrocardiografía Ambulatoria / Síndrome de Brugada Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Am Coll Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos