Your browser doesn't support javascript.
loading
AMPK: The energy sensor at the crossroads of aging and cancer.
Penugurti, Vasudevarao; Manne, Rajesh Kumar; Bai, Ling; Kant, Rajni; Lin, Hui-Kuan.
Afiliación
  • Penugurti V; Department of Pathology, School of Medicine, Duke University, Durham, NC 27710, United States.
  • Manne RK; Department of Pathology, School of Medicine, Duke University, Durham, NC 27710, United States.
  • Bai L; Department of Pathology, School of Medicine, Duke University, Durham, NC 27710, United States.
  • Kant R; Department of Pathology, School of Medicine, Duke University, Durham, NC 27710, United States.
  • Lin HK; Department of Pathology, School of Medicine, Duke University, Durham, NC 27710, United States. Electronic address: Hui-kuan.lin@duke.edu.
Semin Cancer Biol ; 106-107: 15-27, 2024 Aug 26.
Article en En | MEDLINE | ID: mdl-39197808
ABSTRACT
AMP-activated protein kinase (AMPK) is a protein kinase that plays versatile roles in response to a variety of physiological stresses, including glucose deprivation, hypoxia, and ischemia. As a kinase with pleiotropic functions, it plays a complex role in tumor progression, exhibiting both tumor-promoting and tumor-suppressing activities. On one hand, AMPK enhances cancer cell proliferation and survival, promotes cancer metastasis, and impairs anti-tumor immunity. On the other hand, AMPK inhibits cancer cell growth and survival and stimulates immune responses in a context-dependent manner. Apart from these functions, AMPK plays a key role in orchestrating aging and aging-related disorders, including cardiovascular diseases (CVD), Osteoarthritis (OA), and Diabetes. In this review article, we summarized the functions of AMPK pathway based on its oncogenic and tumor-suppressive roles and highlighted the importance of AMPK pathway in regulating cellular aging. We also spotlighted the significant role of various signaling pathways, activators, and inhibitors of AMPK in serving as therapeutic strategies for anti-cancer and anti-aging therapy.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Semin Cancer Biol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Semin Cancer Biol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido