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Defining the Functional Sensitivity for the Siemens Atellica Calcitonin Assay: Insight From a Single-Center Study.
Li, Jieli; Patton, Ashley; Lee, Jason K Y; Scheidegger, Matt; Azaryan, Irina; Sipos, Jennifer A; Nabhan, Fadi; Jones, JoAnna; Algeciras-Schimnich, Alicia; Ringel, Matthew D.
Afiliación
  • Li J; Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, Ohio. Electronic address: Jieli.li@osumc.edu.
  • Patton A; Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
  • Lee JKY; Department of Clinical Laboratory, University Hospital, The Ohio State University, Columbus, Ohio.
  • Scheidegger M; Department of Clinical Laboratory, University Hospital, The Ohio State University, Columbus, Ohio.
  • Azaryan I; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
  • Sipos JA; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
  • Nabhan F; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
  • Jones J; Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
  • Algeciras-Schimnich A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
  • Ringel MD; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, Ohio; Department of Molecular Medicine and Therapeutics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. Electronic address: matthe
Endocr Pract ; 2024 Aug 26.
Article en En | MEDLINE | ID: mdl-39197746
ABSTRACT

BACKGROUND:

Detectable, and especially rising postthyroidectomy serum calcitonin and carcinoembryonic antigen levels, as per American Thyroid Association guidelines, indicate potential disease presence, requiring frequent calcitonin measurement or imaging for early detection of persistent or recurrent medullary thyroid carcinoma. Thus, defining the clinical cutoff value of detection of calcitonin assays relative to imaging and clinical status is crucial for patient care. This study aimed to evaluate postoperative calcitonin levels using the new Siemens Atellica assay system to determine the most appropriate levels for clinical decision-making.

METHODS:

A retrospective analysis was conducted using Siemens Atellica for calcitonin testing on 56 samples from 40 patients between September 27, 2022 and August 11, 2023. Only calcitonin results performed at least 3 months post-total thyroidectomy were included. Imaging studies, within 6 months of the calcitonin report, were assessed. Carcinoembryonic antigen results were also reviewed.

RESULTS:

Precision analysis at 2.94 and 5.24 pg/mL revealed coefficients of variation at 16.49% and 8.87%, respectively. For the evidence of post-total thyroidectomy persistent or recurrent medullary thyroid carcinoma confirmed by imaging, using a 1.89 pg/mL cutoff for calcitonin yielded 43% sensitivity and 67% specificity. Using a 5.00 pg/mL cutoff resulted in 0% sensitivity and 100% specificity.

CONCLUSIONS:

Our findings indicate the potential suitability of a 5 pg/mL calcitonin cutoff on the Siemens Atellica platform for evaluating tumor persistence or recurrence in post-thyroidectomy patients in our institution. However, individual laboratories should establish their own clinical cutoff value when evaluating calcitonin levels for monitoring tumor recurrence post-thyroidectomy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Endocr Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Endocr Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos