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Novel SARS-CoV-2 inhibition properties of the anti-cancer Kang Guan Recipe herbal formula.
Wang, Wei-Jan; Tang, Hsuan-Ting; Ou, Shi-Chen; Shen, Wan-Jou; Chen, Chung-Yu; Li, Yi-Chuan; Chang, Sui-Yuan; Chang, Wei-Chao; Hsueh, Po-Ren; Huang, Sheng-Teng; Hung, Mien-Chie.
Afiliación
  • Wang WJ; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan.
  • Tang HT; Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
  • Ou SC; Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan; School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan.
  • Shen WJ; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
  • Chen CY; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan.
  • Li YC; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.
  • Chang SY; Dept of Clinical Laboratory Sciences and Medical Biotchnology, National Taiwan University College of Medicine, Taipei, Taiwan; Dept of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Chang WC; Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
  • Hsueh PR; Departments of Laboratory Medicine and Internal Medicine, China Medical University Hospital, Taichung, Taiwan; PhD Program for Aging, School of Medicine, China Medical University, Taichung, Taiwan; Department of Laboratory Medicine, School of Medicine, China Medical University, Taichung, Taiwan.
  • Huang ST; Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Research Cancer Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, Tai
  • Hung MC; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Me
Cancer Lett ; : 217198, 2024 Aug 26.
Article en En | MEDLINE | ID: mdl-39197583
ABSTRACT
The ongoing COVID-19 pandemic is a persistent challenge, with continued breakthrough infections despite vaccination efforts. This has spurred interest in alternative preventive measures, including dietary and herbal interventions. Previous research has demonstrated that herbal medicines can not only inhibit cancer progression but also combat viral infections, including COVID-19 by targeting SARS-CoV-2, indicating a multifaceted potential to address both viruses and cancer. Here, we found that the Kang Guan Recipe (KGR), a novel herbal medicine formula, associates with potent inhibition activity against the SARS-CoV-2 viral infection. We demonstrate that KGR exhibits inhibitory activity against several SARS-CoV-2 variants of concern (VOCs). Mechanistically, we found that KGR can block the interaction of the viral spike and human angiotensin-converting enzyme 2 (ACE2). Furthermore, we assessed the inhibitory effect of KGR on SARS-CoV-2 viral entry in vivo, observing that serum samples from healthy human subjects having taken KGR exhibited suppressive activity against SARS-CoV-2 variants. Our investigation provides valuable insights into the potential of KGR as a novel herbal-based preventive and therapeutic strategy against COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Lett Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Lett Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Irlanda