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Promoting effect of sunset yellow on N-methyl N-nitrosourea-induced rat mammary carcinogenesis: Implications of molecular mechanisms.
Salim, Elsayed I; Elbassuny, Malak I; Mahfouz, Magdy E; El Nashar, Eman M; Alghamdi, Maha A; El-Nablaway, Mohammad; Selim, Hend M.
Afiliación
  • Salim EI; Tanta University, Faculty of Science, Department of Zoology, Research Lab. of Molecular Carcinogenesis, Tanta 31527, Egypt. Electronic address: elsayed.salim@science.tanta.edu.eg.
  • Elbassuny MI; Tanta University, Faculty of Science, Department of Zoology, Research Lab. of Molecular Carcinogenesis, Tanta 31527, Egypt.
  • Mahfouz ME; Department of Zoology, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
  • El Nashar EM; Department of Anatomy, College of Medicine, King Khalid University, Abha 62524, Saudi Arabia.
  • Alghamdi MA; Department of General Surgery -breast oncology and endocrine surgery College of Medicine, King Khalid University, Abha 62524, Saudi Arabia.
  • El-Nablaway M; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Box 71666, Riyadh 11597, Saudi Arabia; Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Selim HM; Department of Biochemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt. Electronic address: hend.m.selim@pharm.tanta.edu.eg.
Toxicol Lett ; 401: 13-23, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39197506
ABSTRACT

BACKGROUND:

Nowadays, the use of food additives, such as Sunset Yellow (SY), is growing, which attracted attention to the potential relationship between some diseases and food additives.

AIM:

The study aimed to investigate the role of Sunset Yellow during chemically-induced mammary gland carcinogenesis in Sprague-Dawley rats. MATERIAL AND

METHODS:

Three groups of female rats were intraperitoneally administered with N-methyl-N-nitrosourea (MNU). Group 1 was set on a basal diet. Group 2 was treated with 161.4 mg\kg\day Sunset Yellow (SY). Group 3 was given SY at 80.7 mg\kg\day. Groups 4-6 were not administered MNU; Group 4 received vehicles only. Groups 5 and 6 were administered SY similarly to groups 2 and 3 respectively.

RESULTS:

Sunset Yellow at both doses exerted a significant dose-dependent increase in tumor incidences, multiplicities, volumes, and decreased tumor latency as compared with control. Immunolabeling indexes of the proliferating cell nuclear antigen, estrogen receptor alpha, and progesterone receptor were significantly increased after SY treatment. Oxidative stress markers, serum estrogen, progesterone, and prolactin levels were significantly modified by SY treatment. The mRNA expression of estrogen receptor alpha and epidermal growth factor was up-regulated in SY groups versus control.

CONCLUSION:

Collectively, SY has significantly promoted MNU-induced mammary tumors in rats with underlying mechanisms correlating SY consumption with estrogen disruption and subsequent antioxidative stress discrepancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Azo / Ratas Sprague-Dawley / Neoplasias Mamarias Experimentales / Metilnitrosourea Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Azo / Ratas Sprague-Dawley / Neoplasias Mamarias Experimentales / Metilnitrosourea Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos