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Lipidomics by Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography-High-Resolution Mass Spectrometry in Osteosarcoma: A Pilot Study.
Pontes, João Guilherme de Moraes; Jadranin, Milka; Assalin, Márcia Regina; Quintero Escobar, Melissa; Stanisic, Danijela; Costa, Tássia Brena Barroso Carneiro; van Helvoort Lengert, André; Boldrini, Érica; Morini da Silva, Sandra Regina; Vidal, Daniel Onofre; Liu, Leticia Huan Bacellar; Maschietto, Mariana; Tasic, Ljubica.
Afiliación
  • Pontes JGM; Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
  • Jadranin M; Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
  • Assalin MR; Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoseva 12, 11000 Belgrade, Serbia.
  • Quintero Escobar M; Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
  • Stanisic D; Embrapa Environment, Jaguariúna 13820-000, Brazil.
  • Costa TBBC; Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
  • van Helvoort Lengert A; Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
  • Boldrini É; Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
  • Morini da Silva SR; Molecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos 14784-400, Brazil.
  • Vidal DO; Barretos Children's Cancer Hospital, Barretos 14784-400, Brazil.
  • Liu LHB; Department of Pathology, Barretos Cancer Hospital, Barretos 14784-400, Brazil.
  • Maschietto M; Molecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos 14784-400, Brazil.
  • Tasic L; Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil.
Metabolites ; 14(8)2024 Jul 28.
Article en En | MEDLINE | ID: mdl-39195512
ABSTRACT
Cancer is a complex disease that can also affect the younger population; however, it is responsible for a relatively high mortality rate of children and youth, especially in low- and middle-income countries (LMICs). Besides that, lipidomic studies in this age range are scarce. Therefore, we analyzed blood serum samples from young patients (12 to 35 years) with bone sarcoma (osteosarcoma) and compared their lipidomics to the ones from the control group of samples, named healthy control (HC group), using NMR and LC-MS techniques. Furthermore, differences in the lipidomic profiles between OS patients with and without metastasis indicate higher glycerophosphocholine (GPC) and glycerophospholipid (GPL) levels in osteosarcoma and increased cholesterol, choline, polyunsaturated fatty acids (PUFAs), and glycerols during the metastasis. These differences, detected in the peripheral blood, could be used as biomarkers for liquid biopsy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Metabolites Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Metabolites Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza