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Sphingolipid and Trimethylamine-N-Oxide (TMAO) Levels in Women with Obesity after Combined Physical Training.
Brandao, Camila Fernanda Cunha; Krempf, Michel; Giolo de Carvalho, Flávia; Aguesse, Audrey; Junqueira-Franco, Márcia Varella Morandi; Batitucci, Gabriela; de Freitas, Ellen Cristini; Noronha, Natalia Yumi; Rodrigues, Guilherme da Silva; Junqueira, Gizela Pedroso; Borba, Diego Alcantara; Billon-Crossouard, Stéphanie; Croyal, Mikael; Marchini, Julio Sergio.
Afiliación
  • Brandao CFC; Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil.
  • Krempf M; Department of Physical Education, State University of Minas Gerais, Divinópolis 35500-000, Minas Gerais, Brazil.
  • Giolo de Carvalho F; NUN, INRA, The Research Unit of the Thorax Institute, CHU Nantes, UMR 1280, PhAN, IMAD, CRNH-O, F-44000 Nantes, France.
  • Aguesse A; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil.
  • Junqueira-Franco MVM; NUN, INRA, The Research Unit of the Thorax Institute, CHU Nantes, UMR 1280, PhAN, IMAD, CRNH-O, F-44000 Nantes, France.
  • Batitucci G; Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil.
  • de Freitas EC; Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of São Paulo, Rod. Araraquara-Jau Km 1, Araraquara 14800-000, São Paulo, Brazil.
  • Noronha NY; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil.
  • Rodrigues GDS; Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of São Paulo, Rod. Araraquara-Jau Km 1, Araraquara 14800-000, São Paulo, Brazil.
  • Junqueira GP; Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil.
  • Borba DA; Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil.
  • Billon-Crossouard S; Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil.
  • Croyal M; Department of Physical Education, State University of Minas Gerais, Divinópolis 35500-000, Minas Gerais, Brazil.
  • Marchini JS; NUN, INRA, The Research Unit of the Thorax Institute, CHU Nantes, UMR 1280, PhAN, IMAD, CRNH-O, F-44000 Nantes, France.
Metabolites ; 14(8)2024 Jul 23.
Article en En | MEDLINE | ID: mdl-39195494
ABSTRACT
Obesity causes metabolic changes, such as the development of cardiovascular diseases. Moreover, physical exercise promotes protection against these diseases. Thus, the objective of the present study was to evaluate whether combined physical training can improve the metabolic system of women with obesity, reducing plasma concentrations of trimethylamine N-oxide (TMAO) and sphingolipids, regardless of weight loss. Fourteen obese women (BMI 30-40 kg/m2), aged 20-40 years, sedentary, were submitted to 8 weeks of combined physical training (strength and aerobic exercises). The training was performed three times/week, 55 min/session, at 75-90% maximum heart rate. All participants were evaluated pre- and post-exercise intervention, and their body composition, plasma TMAO, creatinine, lipid profile, and sphingolipid concentrations were recorded. Maximum oxygen consumption (VO2max), Speed lactate threshold 1 (SpeedLT1), and Speed lactate threshold 2 (SpeedLT2) evaluated physical performance.

Results:

After combined exercise, it did not change body composition, but TMAO, total cholesterol, and sphingolipid concentrations significantly decreased (p < 0.05). There was an increase in physical performance by improving VO2max, SpeedLT1, and SpeedLT2 (p < 0.05). The combined physical exercise could induce cardiovascular risk protection by decreasing TMAO in obese women, parallel to physical performance improvement, independent of weight loss.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Metabolites Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Metabolites Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza