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Effects of added 25(OH)D3 with varying standardized total tract digestible phosphorus concentrations on nursery pig performance, bone characteristics, and serum vitamin D status.
Becker, Larissa L; Gebhardt, Jordan T; Tokach, Mike D; Woodworth, Jason C; Goodband, Robert D; DeRouchey, Joel M; Bergstrom, Jon R; Siepker, Christopher L.
Afiliación
  • Becker LL; Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS 66506-0201, USA.
  • Gebhardt JT; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-0201, USA.
  • Tokach MD; Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS 66506-0201, USA.
  • Woodworth JC; Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS 66506-0201, USA.
  • Goodband RD; Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS 66506-0201, USA.
  • DeRouchey JM; Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS 66506-0201, USA.
  • Bergstrom JR; dsm-firmenich, Plainsboro, NJ 08536-1908, USA.
  • Siepker CL; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
J Anim Sci ; 1022024 Jan 03.
Article en En | MEDLINE | ID: mdl-39193832
ABSTRACT
A total of 360 pigs (DNA 600 × 241; initially 5.8 kg) were used in a 45-d growth study to evaluate the effects of adding 25(OH)D3 with 3 levels of standardized total tract digestible (STTD) P on nursery pig growth performance, bone and urine characteristics, and serum vitamin D. Pigs were weaned at 19 d of age and randomly allotted to 1 of 6 dietary treatments with 5 pigs per pen and 12 replications per treatment. Dietary treatments were arranged in a 2 × 3 factorial with main effects of 25(OH)D3 (0 or 50 µg/kg equivalent to 2,000 IU/kg of vitamin D3; Hy-D, dsm-firmenich, Plainsboro, NJ) and STTD P (70%, 100%, or 130% of the NRC [NRC 2012. Nutrient requirements of swine. 11th rev. ed. Natl. Acad. Press, Washington, DC) requirement estimate on a dietary percentage basis]. All diets contained 1,653 IU/kg of vitamin D3. On day 45, 1 pig per pen was euthanized to collect the right fibula, metacarpal, and 2nd and 10th ribs. Overall, increasing STTD P increased (quadratic, P ≤ 0.003) ADG, ADFI, and GF with minimal improvement above 100% of the NRC STTD P requirement estimate. Added 25(OH)D3 had no effect on growth performance. Increasing STTD P decreased urinary Ca concentration (linear, P < 0.001) and increased urinary P concentration (quadratic, P < 0.001). When pigs were fed added 25(OH)D3, serum 25(OH)D3 increased (quadratic, P = 0.005) as STTD P increased but no differences were observed when 25(OH)D3 was not added and STTD P increased (25(OH)D3 × STTD P interaction, P = 0.032). When pigs were fed 25(OH)D3, serum 1,25(OH)2D3 increased (quadratic, P < 0.001) as STTD P decreased but the increase was not significant when no 25(OH)D3 was fed (STTD P × 25(OH)D3 interaction, P = 0.002). Bone ash percentage and weight increased (quadratic, P ≤ 0.065) in all bones as STTD P increased. Added 25(OH)D3 had no effect on bone density or bone ash weight; however, the reduction in bone ash percentage observed with reducing STTD P level tended to be less when 25(OH)D3 was provided (linear interaction, P = 0.098). Increasing STTD P decreased the likelihood of abnormal histologic bone lesions in the 10th rib. In summary, added 25(OH)D3 had limited effect on growth performance; however, an increase in serum concentrations of 25(OH)D3 and 24,25(OH)2D3 was observed. The addition of 25(OH)D3 to P-deficient diets increased percentage bone ash. Increasing STTD P to 100% of NRC [NRC 2012. Nutrient requirements of swine. 11th rev. ed. Natl. Acad. Press, Washington, DC] requirement estimate increased growth and 130% of NRC maximized bone ash.
Vitamin D3 must be activated through a 2-step hydroxylation process to be metabolically active. Dietary addition of 25-hydroxyvitamin D3 [25(OH)D3] bypasses the hydroxylation step in the conversion of vitamin D3 to 25(OH)D3 in the liver and provides a greater concentration of 25(OH)D3 in circulation. The hypothesis of our experiment was that supplementing 25(OH)D3 to existing dietary levels of vitamin D3 would increase pig growth performance and bone development when added to diets deficient or marginally deficient in P. Overall, added 25(OH)D3 had limited effect on growth performance or urine parameters; however, added 25(OH)D3 increased serum concentrations of 25(OH)D3 and 24,25-dihydroxycholecalciferol [24,25(OH)2D3] and increased bone ash when added to diets deficient in P for bone mineralization (70 or 100% of the NRC (2012) standardized total tract digestible [STTD] P requirement estimate). Increasing STTD P to 100% of the NRC (2012) requirement estimate increased growth while 130% of NRC maximized bone ash.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina D / Dieta / Alimentación Animal / Fenómenos Fisiológicos Nutricionales de los Animales Límite: Animals Idioma: En Revista: J Anim Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina D / Dieta / Alimentación Animal / Fenómenos Fisiológicos Nutricionales de los Animales Límite: Animals Idioma: En Revista: J Anim Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos