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Diagnostic Value of Serum KL-6 in Interstitial Lung Diseases.
Zuo, Li; Zhang, Wenhui; Wang, Ying; Qi, Xin.
Afiliación
  • Zuo L; Department of Pulmonary and Critical Care Medicine, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, 100074, People's Republic of China.
  • Zhang W; General Practice Clinic, Sijiqing Town Community Health Service Center of Haidian District, Beijing, 100097, People's Republic of China.
  • Wang Y; Department of Pharmacy, Wangtai Branch of Jincheng General Hospital, Jincheng, 048006, People's Republic of China.
  • Qi X; Department of Pulmonary and Critical Care Medicine, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, 100074, People's Republic of China.
Int J Gen Med ; 17: 3649-3661, 2024.
Article en En | MEDLINE | ID: mdl-39193261
ABSTRACT

Objective:

To explore serum KL-6 level and investigate its diagnostic value in interstitial lung diseases (ILDs).

Methods:

Serum KL-6 level was measured using the chemiluminescent enzyme immunoassay. Statistical analysis was performed for determining the KL-6 concentration of each group.

Results:

KL-6 level (U/mL) in the ILD group was 1388.321 ±1943.116, which was higher than that in the control group, showing a significant statistical difference. ROC curve analysis based on the receiver operating characteristic curve showed the optimal cut-off value of 402.5U/mL, sensitivity of 77.4%, specificity of 93.4%, and accuracy of 89.4%; through Chi-square test with the two groups, the positive rate of KL-6 in patients with ILD was proved to be significantly higher than that in the control group. KL-6 level was 1063.00±504.757 in the idiopathic pulmonary fibrosis (IPF) group, 1346.892 ±1827.252 in the connective tissue disease-associated interstitial lung disease (CTD-ILD) group, 467.889±288.859 in the organizing pneumonia (OP) group, 8252.333±6050.625 in the pulmonary alveolar proteinosis (PAP) group, and 359.200±392.707 in the sarcoidosis group. The rank sum test showed that the differences were statistically significant. KL-6 level was the lowest in the sarcoidosis group, followed by that in the OP group.

Conclusion:

Serum KL-6 level was confirmed to be highly sensitive, specific, and accurate in the diagnosis of ILD. Subgroup analysis showed that the KL-6 level was the lowest in the sarcoidosis group, followed by that in the OP group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Gen Med Año: 2024 Tipo del documento: Article Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Gen Med Año: 2024 Tipo del documento: Article Pais de publicación: Nueva Zelanda