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Circulating inflammatory cytokines and sarcopenia-related traits: a mendelian randomization analysis.
Sun, Aochuan; Liu, Saiya; Yin, Fen; Li, Zhuangzhuang; Liu, Zhengtang.
Afiliación
  • Sun A; Graduate School, Beijing University of Chinese Medicine, Beijing, China.
  • Liu S; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  • Yin F; Graduate School, Beijing University of Chinese Medicine, Beijing, China.
  • Li Z; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
  • Liu Z; Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Med (Lausanne) ; 11: 1351376, 2024.
Article en En | MEDLINE | ID: mdl-39193020
ABSTRACT

Objective:

To explore the causal relationships between 91 circulating inflammatory cytokines and sarcopenia-related traits (low hand grip strength, appendicular lean mass, and usual walking pace) by Mendelian randomized analysis.

Methods:

Independent genetic variations of inflammatory cytokines and sarcopenia-related traits were selected as instrumental variables from publicly available genome-wide association studies (GWAS). The MR analysis was primarily conducted using the inverse variance-weighted (IVW) method. Sensitivity analyses included Steiger filtering and MR PRESSO, with additional assessments for heterogeneity and pleiotropy.

Results:

The IVW method indicated a causal relationship between Vascular Endothelial Growth Factor A (VEGF-A) and low hand grip strength (OR = 1.05654, 95% CI 1.02453 to 1.08956, P = 0.00046). Additionally, Tumor Necrosis Factor-beta (TNF-ß) was found to have a causal relationship with appendicular lean mass (ALM) (ß = 0.04255, 95% CI 0.02838 to 0.05672, P = 3.96E-09). There was no evidence suggesting a significant causal relationship between inflammatory cytokines and usual walking pace.

Conclusion:

Our research substantiated the causal association between inflammatory cytokines, such as VEGF-A and TNF-ß, and sarcopenia. This finding may provide new avenues for future clinical treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Med (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Med (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza