Your browser doesn't support javascript.
loading
Metagenomic Analysis Reveals Large-Scale Disruptions of the Gut Microbiome in Parkinson's Disease.
Metcalfe-Roach, Avril; Cirstea, Mihai S; Yu, Adam C; Ramay, Hena R; Coker, Olabisi; Boroomand, Seti; Kharazyan, Faezeh; Martino, Davide; Sycuro, Laura K; Appel-Cresswell, Silke; Finlay, B Brett.
Afiliación
  • Metcalfe-Roach A; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Cirstea MS; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
  • Yu AC; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Ramay HR; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
  • Coker O; Pacific Parkinson's Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Boroomand S; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Kharazyan F; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Martino D; Borgland Family Brain Tissue and DNA Bank, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Sycuro LK; Borgland Family Brain Tissue and DNA Bank, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Appel-Cresswell S; Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
  • Finlay BB; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Mov Disord ; 2024 Aug 28.
Article en En | MEDLINE | ID: mdl-39192744
ABSTRACT

BACKGROUND:

Parkinson's disease (PD) has been consistently linked to alterations within the gut microbiome.

OBJECTIVE:

Our goal was to identify microbial features associated with PD incidence and progression.

METHODS:

Metagenomic sequencing was used to characterize taxonomic and functional changes to the PD microbiome and to explore their relation to bacterial metabolites and disease progression. Motor and non-motor symptoms were tracked using Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and levodopa equivalent dose across ≤5 yearly study visits. Stool samples were collected at baseline for metagenomic sequencing (176 PD, 100 controls).

RESULTS:

PD-derived stool samples had reduced intermicrobial connectivity and seven differentially abundant species compared to controls. A suite of bacterial functions differed between PD and controls, including depletion of carbohydrate degradation pathways and enrichment of ribosomal genes. Faecalibacterium prausnitzii-specific reads contributed significantly to more than half of all differentially abundant functional terms. A subset of disease-associated functional terms correlated with faster progression of MDS-UPDRS part IV and separated those with slow and fast progression with moderate accuracy within a random forest model (area under curve = 0.70). Most PD-associated microbial trends were stronger in those with symmetric motor symptoms.

CONCLUSION:

We provide further evidence that the PD microbiome is characterized by reduced intermicrobial communication and a shift to proteolytic metabolism in lieu of short-chain fatty acid production, and suggest that these microbial alterations may be relevant to disease progression. We also describe how our results support the existence of gut-first versus brain-first PD subtypes. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos