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[Effect of Collagen Peptides on Function of Mouse T Lymphocytes under Simulated Microgravity].
Si, Shao-Yan; Qin, Ya-Ya; Wu, Ying-Ying; Ma, Xiao-Yu; Shang, Ying; Song, Shu-Jun; Guo, Yan-Chuan.
Afiliación
  • Si SY; Department of Comprehensive Basic Experiment (Division Two), Strategic Support Force Medical Center, Beijing 100101, China.
  • Qin YY; Department of Comprehensive Basic Experiment (Division Two), Strategic Support Force Medical Center, Beijing 100101, China.
  • Wu YY; Department of Comprehensive Basic Experiment (Division Two), Strategic Support Force Medical Center, Beijing 100101, China.
  • Ma XY; Department of Comprehensive Basic Experiment (Division Two), Strategic Support Force Medical Center, Beijing 100101, China.
  • Shang Y; Department of Comprehensive Basic Experiment (Division Two), Strategic Support Force Medical Center, Beijing 100101, China.
  • Song SJ; Department of Comprehensive Basic Experiment (Division Two), Strategic Support Force Medical Center, Beijing 100101, China.
  • Guo YC; Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Beijing 100190, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 32(4): 1258-1263, 2024 Aug.
Article en Zh | MEDLINE | ID: mdl-39192428
ABSTRACT

OBJECTIVE:

To understand the effect of collagen peptides on the function of mouse lymphocytes under simulated microgravity.

METHODS:

The splenocytes of mice were isolated, and the rotary cell culture system was used to simulate the microgravity. The T lymphocytes were stimulated with mitotic agents, concanavalin A (ConA), and the cells were treated with different concentrations of collagen peptides. The proliferation of lymphocytes and the levels of cytokines in the supernatant were detected.

RESULTS:

Simulated microgravity could inhibit the proliferation of spleen T lymphocytes and decrease the level of cytokines in the supernatant. Collagen peptides could promote the lymphocyte proliferation and cytokine production in cells cultured under simulated microgravity.

CONCLUSION:

Collagen peptides may attenuate the inhibitory effect of simulated microgravity on T lymphocytes by regulating the cell proliferation and the secretion of cytokines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Bazo / Linfocitos T / Citocinas / Colágeno / Simulación de Ingravidez / Proliferación Celular Límite: Animals Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Bazo / Linfocitos T / Citocinas / Colágeno / Simulación de Ingravidez / Proliferación Celular Límite: Animals Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China