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Host specificity and cophylogeny in the "animal-gut bacteria-phage" tripartite system.
Feng, Ye; Wei, Ruike; Chen, Qiuli; Shang, Tongyao; Zhou, Nihong; Wang, Zeyu; Chen, Yanping; Chen, Gongwen; Zhang, Guozhi; Dong, Kun; Zhong, Yihai; Zhao, Hongxia; Hu, Fuliang; Zheng, Huoqing.
Afiliación
  • Feng Y; Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. pandafengye@zju.edu.cn.
  • Wei R; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China. pandafengye@zju.edu.cn.
  • Chen Q; College of Animal Sciences, Zhejiang University, Hangzhou, China.
  • Shang T; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
  • Zhou N; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
  • Wang Z; College of Animal Sciences, Zhejiang University, Hangzhou, China.
  • Chen Y; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
  • Chen G; USDA-ARS Bee Research Laboratory, Beltsville, MD, USA.
  • Zhang G; College of Animal Sciences, Zhejiang University, Hangzhou, China.
  • Dong K; College of Animal Sciences, Zhejiang University, Hangzhou, China.
  • Zhong Y; Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.
  • Zhao H; Environment and Plant Protection Institute, Chinese Academy of Tropical Agriculture Sciences, Haikou, Hainan, China.
  • Hu F; Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China.
  • Zheng H; College of Animal Sciences, Zhejiang University, Hangzhou, China.
NPJ Biofilms Microbiomes ; 10(1): 72, 2024 Aug 27.
Article en En | MEDLINE | ID: mdl-39191812
ABSTRACT
Cophylogeny has been identified between gut bacteria and their animal host and is highly relevant to host health, but little research has extended to gut bacteriophages. Here we use bee model to investigate host specificity and cophylogeny in the "animal-gut bacteria-phage" tripartite system. Through metagenomic sequencing upon different bee species, the gut phageome revealed a more variable composition than the gut bacteriome. Nevertheless, the bacteriome and the phageome showed a significant association of their dissimilarity matrices, indicating a reciprocal interaction between the two kinds of communities. Most of the gut phages were host generalist at the viral cluster level but host specialist at the viral OTU level. While the dominant gut bacteria Gilliamella and Snodgrassella exhibited matched phylogeny with bee hosts, most of their phages showed a diminished level of cophylogeny. The evolutionary rates of the bee, the gut bacteria and the gut phages showed a remarkably increasing trend, including synonymous and non-synonymous substitution and gene content variation. For all of the three codiversified tripartite members, however, their genes under positive selection and genes involving gain/loss during evolution simultaneously enriched the functions into metabolism of nutrients, therefore highlighting the tripartite coevolution that results in an enhanced ecological fitness for the whole holobiont.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Bacterias / Bacteriófagos / Especificidad del Huésped / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: NPJ Biofilms Microbiomes Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Bacterias / Bacteriófagos / Especificidad del Huésped / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: NPJ Biofilms Microbiomes Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos