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Worse Wilms' Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs.
Rigby, Kasey L; Diaz, Michael J; Gozlan, Etienne C; Kacsoh, Dorottya B; Song, Joanna J; Hudock, Tabitha R; Chobrutskiy, Andrea; Chobrutskiy, Boris I; Blanck, George.
Afiliación
  • Rigby KL; University of Central Florida College of Medicine, Orlando, FL, U.S.A.
  • Diaz MJ; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
  • Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
  • Kacsoh DB; University of Central Florida College of Medicine, Orlando, FL, U.S.A.
  • Song JJ; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
  • Hudock TR; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
  • Chobrutskiy A; Department of Pediatrics, Oregon Health and Science University Hospital, Portland, OR, U.S.A.
  • Chobrutskiy BI; Department of Internal Medicine, Oregon Health and Science University Hospital, Portland, OR, U.S.A.
  • Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.; gblanck@usf.edu.
Cancer Genomics Proteomics ; 21(5): 439-447, 2024.
Article en En | MEDLINE | ID: mdl-39191494
ABSTRACT
BACKGROUND/

AIM:

Wilms' tumors are pediatric renal tumors that generally have a good prognosis and outcomes. Viral illnesses have been linked to development of neoplasms and should be considered as a factor that could modulate overall survival. MATERIALS AND

METHODS:

We considered recently developed adaptive immune receptor, genomics and bioinformatics approaches to assess the potential impact of cytomegalovirus (CMV) infections in Wilms' tumor.

RESULTS:

T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences from Wilms' tumor specimens represented by the Therapeutically Applicable Research to Generate Effective Treatments dataset were compared with known anti-CMV TCR CDR3s, indicating that cases representing the anti-CMV TCR CDR3s had worse outcomes. Then, a chemical complementarity scoring approach for the Wilms' tumor, TCR CDR3s and a series of CMV antigens further indicated that cases representing a higher chemical complementarity to the CMV antigens had worse outcomes.

CONCLUSION:

Overall, we present a potentially novel method to assess CMV infections and identify patients who could benefit from therapies that address such infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Tumor de Wilms / Regiones Determinantes de Complementariedad / Citomegalovirus / Neoplasias Renales Límite: Humans Idioma: En Revista: Cancer Genomics Proteomics Asunto de la revista: BIOQUIMICA / GENETICA MEDICA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Tumor de Wilms / Regiones Determinantes de Complementariedad / Citomegalovirus / Neoplasias Renales Límite: Humans Idioma: En Revista: Cancer Genomics Proteomics Asunto de la revista: BIOQUIMICA / GENETICA MEDICA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Grecia