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The impact of ACTH levels on neurotransmitters and antioxidants in patients with major depressive disorder: A novel investigation.
Tian, Shiyun; Liu, Meichen; Yang, Chun; Du, Wei; Gao, Bingbing; Li, Mengying; Pan, Tao; Liu, Tieli; Song, Qingwei; Lin, Liangjie; Zhang, Huimin; Miao, Yanwei.
Afiliación
  • Tian S; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Liu M; Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Yang C; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Du W; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Gao B; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Li M; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Pan T; Department of Interventional Therapy, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Liu T; School of Medical Imaging, Dalian Medical University, Dalian, China.
  • Song Q; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Lin L; Clinical and Technical Support, Philips Healthcare, Beijing, China.
  • Zhang H; Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address: huiminzhangxs@163.com.
  • Miao Y; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address: ywmiao716@163.com.
J Affect Disord ; 365: 587-596, 2024 Nov 15.
Article en En | MEDLINE | ID: mdl-39191311
ABSTRACT

BACKGROUND:

The relationship between neurotransmitters and oxidative stress in Major Depressive Disorder (MDD) patients, considering HPA axis activity and psychological and cognitive states, is unclear. This study examines changes in neurotransmitters (GABA, Glx) and antioxidants (GSH) in the dorsal anterior cingulate cortex (dACC) of MDD patients under varying levels of ACTH, and their relationship with psychological and cognitive conditions.

METHODS:

Forty-five MDD patients were divided into high-ACTH (>65 pg/mL; n = 16) and normal-ACTH (7-65 pg/mL; n = 29) groups based on blood ACTH levels, along with 12 healthy controls (HC). All participants underwent HAM-D, HAM-A assessments, and most completed MMSE and MoCA tests. GABA+, Glx, and GSH levels in the dACC were measured using the MEGA-PRESS sequence. Intergroup differences and correlations between clinical factors, HPA axis activity, and metabolites were analyzed.

RESULTS:

Compared to HC, the normal ACTH group showed higher Glx and lower GSH levels. Glx and GSH were negatively correlated with MDD severity. In the high-ACTH MDD group, Glx positively correlated with delayed memory, and GSH positively correlated with abstraction. Factors influencing GABA included ACTH levels, depression duration, and negative events. Predictive factors for HAM-D scores were GSH and GABA.

LIMITATIONS:

The sample size is small.

CONCLUSION:

MDD patients exhibit neurochemical differences in the brain related to HPA axis levels, MDD severity, and cognitive function. Clinical factors, neurotransmitters, and neuroendocrine levels significantly influence depression severity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Adrenocorticotrópica / Neurotransmisores / Trastorno Depresivo Mayor / Ácido gamma-Aminobutírico / Giro del Cíngulo / Antioxidantes Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Adrenocorticotrópica / Neurotransmisores / Trastorno Depresivo Mayor / Ácido gamma-Aminobutírico / Giro del Cíngulo / Antioxidantes Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos