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Brain mechanisms of rumination and negative self-referential processing in adolescent depression.
Murray, Laura; Jaffe, Nigel M; Tierney, Anna O; Pidvirny, Kristina; Balkind, Emma G; Abbasi, Batool S; Brown, Miranda; Webb, Christian A.
Afiliación
  • Murray L; Cognitive and Pharmacological Neuroimaging Unit, National Institute on Drug Abuse, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, United States of America; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America. Electronic address: Laura.murray@nih.gov.
  • Jaffe NM; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America.
  • Tierney AO; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America.
  • Pidvirny K; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America.
  • Balkind EG; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America.
  • Abbasi BS; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America.
  • Brown M; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America.
  • Webb CA; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, United States of America.
J Affect Disord ; 366: 83-90, 2024 Dec 01.
Article en En | MEDLINE | ID: mdl-39191310
ABSTRACT

BACKGROUND:

Depression is linked to cognitive biases towards more negative and less positive self-relevant information. Rumination, perseverative negative thinking about the past and the self, may contribute to these biases.

METHODS:

159 adolescents (12-18 years), with a range of depression symptoms, completed the SRET during fMRI. Multiple regressions tested associations between conventional self-report and ecological momentary assessment (EMA) measured rumination, and neural and behavioral responses during a self-referent encoding task (SRET).

RESULTS:

Higher rumination (conventional self-report and EMA) was associated with more negative and fewer positive words endorsed and recalled. Higher self-reported (but not EMA) rumination was associated with higher accuracy in recognizing negative words and greater insula and dorsal anterior cingulate activity to negative versus positive words.

LIMITATIONS:

The sample included mostly non-Hispanic White participants with household incomes above the national average, highlighting the need for replication in more diverse samples. Word endorsement discrepancies required fMRI analyses to model neural response to viewing negative versus positive words.

CONCLUSIONS:

Adolescents with higher rumination endorsed and recalled more negative and fewer positive words and recognized more negative words during the SRET. Higher insula reactivity, a key region for modulating externally-oriented attention and internally-oriented self-referential processes, may contribute to links between rumination and negative memory biases. These findings provide insight into neurocognitive mechanisms underlying depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Rumiación Cognitiva Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Rumiación Cognitiva Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos