Your browser doesn't support javascript.
loading
Incidence and Predictors of Stroke in Australian Adults With Congenital Heart Disease (2000-2017).
Sodhi-Berry, Nita; Burchill, Luke J; Kleinig, Timothy J; Nedkoff, Lee; Katzenellenbogen, Judith M.
Afiliación
  • Sodhi-Berry N; Cardiovascular Epidemiology Research Centre, School of Population and Global Health The University of Western Australia Crawley WA Australia.
  • Burchill LJ; Department of Cardiovascular Medicine Mayo Clinic College of Medicine Rochester MN USA.
  • Kleinig TJ; Department of Medicine, Royal Melbourne Hospital University of Melbourne Parkville VIC Australia.
  • Nedkoff L; Department of Neurology Royal Adelaide Hospital Adelaide SA Australia.
  • Katzenellenbogen JM; Cardiovascular Epidemiology Research Centre, School of Population and Global Health The University of Western Australia Crawley WA Australia.
J Am Heart Assoc ; 13(17): e034057, 2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39190566
ABSTRACT

BACKGROUND:

Adults with congenital heart disease (CHD) are at increased risk of stroke but high-quality population level data on stroke incidence in these patients are scant. METHODS AND

RESULTS:

A retrospective whole-population Western Australian cohort of adult patients with CHD aged 18 to 64 years was created and followed from January 2000 to December 2017 using linked hospital data. Stroke incidence rates within the adult cohort with CHD were calculated and compared with the general population via direct standardization. A nested case-control design assessed predictors of ischemic and hemorrhagic stroke within the cohort. Among 7916 adults with CHD, 249 (3.1%) incident strokes occurred at a median age of 47 years; 186 (2.3%) ischemic, 33 (0.4%) hemorrhagic and 30 (0.4%) unspecified strokes. Ischemic and hemorrhagic stroke incidence was, respectively, 9 and 3 times higher in adults with CHD than the general population. Absolute risk was low with annual rates of 0.26% (ischemic) and 0.05% (hemorrhagic). Highest rates were observed in adults with shunt and left-sided lesions. Predictors of ischemic stroke in adults with CHD included recent cardiac surgery, left-sided valve repair/replacements, shunt lesions, and traditional risk factors (hypertension, infective endocarditis, peripheral vascular disease, and tobacco use). Mental health disorders and increasing Charlson's comorbidity scores were strongly associated with higher risk of ischemic and hemorrhagic stroke. The CHA2DS2VASc score was associated with ischemic stroke incidence.

CONCLUSIONS:

This study provides the first population-based stroke incidence estimates for adults with CHD in Australia, showing elevated stroke risk across different CHD lesions. It highlights the potential clinical importance of managing comorbidities, especially mental health.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiopatías Congénitas Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiopatías Congénitas Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido