Your browser doesn't support javascript.
loading
Bilayer hydrogel with a protective film and a regenerative hydrogel for effective diabetic wound treatment.
Zhang, Jinfeng; Li, Jing; Zhang, Yang; Zhao, Yueshui; Shen, Jing; Du, Fukuan; Chen, Yu; Li, Mingxing; Wu, Xu; Chen, Meijuan; Xiao, Zhangang; Deng, Shuai.
Afiliación
  • Zhang J; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China. zhangangxiao@swmu.edu.cn.
  • Li J; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China. zhangangxiao@swmu.edu.cn.
  • Zhang Y; Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, China.
  • Zhao Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China. zhangangxiao@swmu.edu.cn.
  • Shen J; Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, Sichuan, China.
  • Du F; South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China.
  • Chen Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China. zhangangxiao@swmu.edu.cn.
  • Li M; Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, Sichuan, China.
  • Wu X; South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China.
  • Chen M; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China. zhangangxiao@swmu.edu.cn.
  • Xiao Z; Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, Sichuan, China.
  • Deng S; South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China.
Biomater Sci ; 12(19): 5036-5051, 2024 Sep 25.
Article en En | MEDLINE | ID: mdl-39189321
ABSTRACT
Diabetic foot ulcers (DFUs) are one of the most serious complications of diabetes, often leading to necrosis and amputation. DFU is caused by the intricate diabetic microenvironment, including ischemia, hypoxia, hyperinflammation, reduced angiogenesis, and persistent infection. Traditional wound dressings made of single or mixed materials often struggle to meet all the requirements for effective diabetic wound healing. In contrast, multilayer dressings comprising more than single layers have the potential to address these challenges by combining their diverse chemical and physical properties. In this study, we developed a bilayer hydrogel comprising a GelMA-ALG-nano-ZnO protective film and a COL1-PRP regenerative hydrogel for facilitating diabetic wound healing. We demonstrated the protective properties against bacterial infection of the protective film, while highlighting the regenerative potential of the COL1-PRP hydrogel in promoting fibroblast and MUVEC migration, extracellular matrix secretion and deposition, and angiogenesis. Importantly, the bilayer hydrogel exhibited superior efficacy in promoting full-thickness wound healing in a diabetic rat model compared to its single-layer hydrogel counterparts. This multi-layer approach offers a promising strategy for addressing the complexities of diabetic foot treatment and improving clinical outcomes.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Ratas Sprague-Dawley / Pie Diabético / Hidrogeles / Diabetes Mellitus Experimental Límite: Animals / Humans / Male Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Ratas Sprague-Dawley / Pie Diabético / Hidrogeles / Diabetes Mellitus Experimental Límite: Animals / Humans / Male Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido