Your browser doesn't support javascript.
loading
The safety of magnetic resonance imaging contrast agents.
Cunningham, Amy; Kirk, Martin; Hong, Emily; Yang, Jing; Howard, Tamara; Brearley, Adrian; Sáenz-Trevizo, Angelica; Krawchuck, Jacob; Watt, John; Henderson, Ian; Dokladny, Karol; DeAguero, Joshua; Escobar, G Patricia; Wagner, Brent.
Afiliación
  • Cunningham A; School of Medicine, University of New Mexico Health Science Center, Albuquerque, NM, United States.
  • Kirk M; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM, United States.
  • Hong E; School of Medicine, University of New Mexico Health Science Center, Albuquerque, NM, United States.
  • Yang J; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM, United States.
  • Howard T; Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM, United States.
  • Brearley A; Department of Earth and Planetary Sciences, University of New Mexico, Albuquerque, NM, United States.
  • Sáenz-Trevizo A; Department of Earth and Planetary Sciences, University of New Mexico, Albuquerque, NM, United States.
  • Krawchuck J; Sandia National Laboratory, Center for Integrated Nanotechnologies, Albuquerque, NM, United States.
  • Watt J; Los Alamos National Laboratory, Center for Integrated Nanotechnologies, Albuquerque, NM, United States.
  • Henderson I; Omphalos Bioscience, Albuquerque, NM, United States.
  • Dokladny K; Kidney Institute of New Mexico, University of New Mexico Health Science Center, Kidney Institute of New Mexico, Albuquerque, NM, United States.
  • DeAguero J; Kidney Institute of New Mexico, University of New Mexico Health Science Center, Kidney Institute of New Mexico, Albuquerque, NM, United States.
  • Escobar GP; Kidney Institute of New Mexico, University of New Mexico Health Science Center, Kidney Institute of New Mexico, Albuquerque, NM, United States.
  • Wagner B; Kidney Institute of New Mexico, University of New Mexico Health Science Center, Kidney Institute of New Mexico, Albuquerque, NM, United States.
Front Toxicol ; 6: 1376587, 2024.
Article en En | MEDLINE | ID: mdl-39188505
ABSTRACT
Gadolinium-based contrast agents are increasingly used in clinical practice. While these pharmaceuticals are verified causal agents in nephrogenic systemic fibrosis, there is a growing body of literature supporting their role as causal agents in symptoms associated with gadolinium exposure after intravenous use and encephalopathy following intrathecal administration. Gadolinium-based contrast agents are multidentate organic ligands that strongly bind the metal ion to reduce the toxicity of the metal. The notion that cationic gadolinium dissociates from these chelates and causes the disease is prevalent among patients and providers. We hypothesize that non-ligand-bound (soluble) gadolinium will be exceedingly low in patients. Soluble, ionic gadolinium is not likely to be the initial step in mediating any disease. The Kidney Institute of New Mexico was the first to identify gadolinium-rich nanoparticles in skin and kidney tissues from magnetic resonance imaging contrast agents in rodents. In 2023, they found similar nanoparticles in the kidney cells of humans with normal renal function, likely from contrast agents. We suspect these nanoparticles are the mediators of chronic toxicity from magnetic resonance imaging contrast agents. This article explores associations between gadolinium contrast and adverse health outcomes supported by clinical reports and rodent models.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Toxicol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Toxicol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza