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Lung function and health-related quality of life among adult patients following pulmonary TB treatment.
Zawedde, J; Abelman, R; Musisi, E; Nyabigambo, A; Sanyu, I; Kaswabuli, S; Byanyima, P; Lewis, E; Sessolo, A; Lalitha, R; Kiwanuka, N; Crothers, K; Worodria, W; Davis, J L; Huang, L.
Afiliación
  • Zawedde J; Makerere University School of Public Health, Kampala, Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Abelman R; Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA.
  • Musisi E; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Nyabigambo A; Makerere University School of Public Health, Kampala.
  • Sanyu I; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Kaswabuli S; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Byanyima P; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Lewis E; Department of Anesthesia, San Francisco General Hospital, San Francisco, CA, USA.
  • Sessolo A; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Lalitha R; Makerere University College of Health Sciences; Kampala, Uganda.
  • Kiwanuka N; Makerere University School of Public Health, Kampala.
  • Crothers K; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA.
  • Worodria W; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Davis JL; Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT.
  • Huang L; Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.
Int J Tuberc Lung Dis ; 28(9): 419-426, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-39187999
ABSTRACT
OBJECTIVESPulmonary TB (PTB) increases the risk of chronic lung complications, which are associated with increased morbidity and mortality. We determined the prevalence and predictors of post-TB lung disease and persistent symptoms in a resource-limited setting.<a class="decs" id="22045">METHODS</a>Adults who completed PTB treatment underwent spirometry and completed the St. George's Respiratory Questionnaire (SGRQ), a questionnaire that assesses quality of life on symptom, activity, and impact. We performed multivariate analyses to calculate the X-adjusted prevalence ratio (PRadj) of abnormal spirometry and identify associated risk factors.RESULTSAmong the 162 participants, 89 (54.9%) were male. The median age was 32 years, and 65 (40.1%) had HIV. Overall, 65 participants (40.1%) had abnormal lung function, with spirometric restriction seen in 29.0%, obstruction in 4.9%, and a mixed pattern in 6.2%. Smoking (PRadj 1.88, 95% CI 1.11-3.16; P = 0.02) and female sex (PRadj 1.81, 95% Cl 1.15-2.84; P = 0.01) were independent risk factors for abnormal lung function. The median SGRQ scores were higher in participants with cavitation (P < 0.001) or bilateral consolidation on initial chest X-ray (P = 0.01).CONCLUSIONSLung function abnormalities, particularly spirometric restriction, are common in patients completing PTB treatment. Female sex and smoking status were associated with lung function abnormalities; therefore, additional studies to understand the underlying mechanistic pathways are warranted..
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Espirometría / Tuberculosis Pulmonar Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Tuberc Lung Dis Año: 2024 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Espirometría / Tuberculosis Pulmonar Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Tuberc Lung Dis Año: 2024 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Francia