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Association of monoaminergic gene polymorphisms in chronic inflammatory pulmonary disease patients with successful smoking cessation.
Mikaczo, Angela; Papp, Csaba; Erdei, Tamas; Posa, Aniko; Zahuczky, Gabor; Varga, Csaba; Szabo, Janos; Gesztelyi, Rudolf; Szilasi, Maria; Zsuga, Judit.
Afiliación
  • Mikaczo A; Department of Pulmonology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.
  • Papp C; Doctoral School of Pharmaceutical Sciences, University of Debrecen, Debrecen, H-4032, Hungary.
  • Erdei T; Department of Psychiatry, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H- 4032, Hungary.
  • Posa A; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.
  • Zahuczky G; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary.
  • Varga C; Department of Psychiatry, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H- 4032, Hungary.
  • Szabo J; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary.
  • Gesztelyi R; Department of Psychiatry, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H- 4032, Hungary.
  • Szilasi M; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H-4032, Hungary. gesztelyi.rudolf@pharm.unideb.hu.
  • Zsuga J; Department of Pulmonology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.
BMC Pulm Med ; 24(1): 411, 2024 Aug 26.
Article en En | MEDLINE | ID: mdl-39187813
ABSTRACT

BACKGROUND:

Albeit smoking cessation has unequivocal health benefits, attempts to quit are not unanimous, even in patient populations at high risk for smoking-related diseases cessation. Allelic variations of enzymes involved in dopamine metabolism are being considered as candidates for nicotine addiction. We set out to assess whether rs4680 G/A and rs2235186 G/A polymorphisms of COMT and MAO-A, respectively are associated with the ability to quit smoking in chronic inflammatory pulmonary disease patients.

METHODS:

Patients managed for chronic inflammatory pulmonary disease by the Department of Pulmonology (University of Debrecen, Hungary), with a current or past smoking habit were included in the current analysis. The study was designed in line with the STROBE statement for cross-sectional studies and was approved by the National Center for Public Health, Hungary. Genomic DNA was extracted from peripheral blood specimens. SNPs were genotyped using TaqMan SNP genotyping assays.

RESULTS:

rs4680 COMT polymorphism showed significant effect for successful smoking cessation in patients with pulmonary disease. Accordingly, A/A subjects had lower odds for successful smoking cessation (odds ratio 0.37; 95% confidence interval 0.20-0.69, p = 0.002 (additive model). On the other hand, patients homozygous for the minor allele (A) at rs2235186 of MAO-A showed a non-significant trend toward increased odds for successful smoking cessation.

CONCLUSIONS:

The presence of the minor allele for rs4680 COMT was shown to decrease the odds for successful smoking cessation, a finding that may be interpreted in view of the altered balance between tonic and phasic dopamine release.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecol O-Metiltransferasa / Cese del Hábito de Fumar / Polimorfismo de Nucleótido Simple / Monoaminooxidasa Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: BMC Pulm Med Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecol O-Metiltransferasa / Cese del Hábito de Fumar / Polimorfismo de Nucleótido Simple / Monoaminooxidasa Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: BMC Pulm Med Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido