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Management of the Axilla After Neoadjuvant Chemotherapy: Can Axillary Needle Biopsy Replace Sentinel Node Biopsy?
Yildirim, Emine; Basim, Pelin; Ucar, Nese; Bektas, Sibel; Iscen, Kutay; Karci, Ebru; Ozdemir, Asena Ayca.
Afiliación
  • Yildirim E; Department of General Surgery, University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey; opdreyildirim@gmail.com.
  • Basim P; Department of General Surgery, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.
  • Ucar N; Department of Radiology, University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.
  • Bektas S; Department of Pathology, University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.
  • Iscen K; Department of General Surgery, University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.
  • Karci E; Department of Oncology, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.
  • Ozdemir AA; Department of Medical Education, Faculty of Medicine, Mersin University, Mersin, Turkey.
In Vivo ; 38(5): 2523-2530, 2024.
Article en En | MEDLINE | ID: mdl-39187354
ABSTRACT
BACKGROUND/

AIM:

The aim of the study was to investigate whether it is possible to evaluate the axilla after treatment without performing sentinel lymph node biopsy (SLNB) in breast cancer patients with biopsy-proven axillary lymph node metastases who received neoadjuvant chemotherapy (NAC). PATIENTS AND

METHODS:

This prospective, randomized, clinically designed study included patients with clinical T1-3 and biopsy-proven N1 breast cancer. Prior to the surgery scheduled after NAC, the patients were randomized into two groups. A biopsy sample was obtained from the clipped axillary lymph node, which was preoperatively known to be metastatic, using fine needle aspiration (FNAB) in the first group and core needle biopsy (CNB) in the second group. The predictive ability of the two biopsy methods for the SLNB results was evaluated.

RESULTS:

The study included 50 female patients with breast cancer, with a mean age of 48.4±10.72 years. In both groups, metastasis was detected in nine patients, and no metastasis was seen in 14 patients. In intergroup comparisons, all patients with metastasis in the FNAB group also had metastasis according to SLNB, while 21.4% of the cases without metastasis in this group were metastatic according to SLNB. In the CNB group, metastasis was observed in all patients with metastasis according to SLNB, while no metastasis was detected in those who were reported to have no metastasis by SLNB. The accuracy, specificity, and sensitivity values for the prediction of SLNB results were all found to be 100% for CNB, whereas they were 87%, 100%, and 75%, respectively, for FNAB.

CONCLUSION:

Both CNB and FNAB could potentially replace SLNB due to their high accuracy rates in evaluating the axilla after NAC. The sensitivity and accuracy of CNB were determined to be higher.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axila / Neoplasias de la Mama / Terapia Neoadyuvante / Biopsia del Ganglio Linfático Centinela / Metástasis Linfática Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axila / Neoplasias de la Mama / Terapia Neoadyuvante / Biopsia del Ganglio Linfático Centinela / Metástasis Linfática Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia