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Restoration of Spatial Learning Through Oral Administration of Lipopolysaccharides in Diabetes-related Cognitive Dysfunction.
Inagawa, Hiroyuki; Oda, Masataka; Tjhin, Vindy Tjendana; Kohchi, Chie; Soma, Gen-Ichiro.
Afiliación
  • Inagawa H; Control of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
  • Oda M; Macrophi Inc., Kagawa, Japan.
  • Tjhin VT; Research Institute for Healthy Living, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
  • Kohchi C; Control of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
  • Soma GI; Control of Innate Immunity, Collaborative Innovation Partnership, Kagawa, Japan.
In Vivo ; 38(5): 2190-2196, 2024.
Article en En | MEDLINE | ID: mdl-39187339
ABSTRACT
BACKGROUND/

AIM:

In a previous report, our group showed that oral administration of lipopolysaccharides (LPS) from Pantoea agglomerans can prevent the progression of streptozotocin (STZ)-induced diabetes-related cognitive dysfunction (DRCD) in mice without causing significant side-effects. However, the treatment effects of oral administration of LPS to DRCD remain unknown. MATERIALS AND

METHODS:

We modified our previous animal experimental model to investigate whether oral administration of LPS can recover cognitive function after DRCD onset.

RESULTS:

The Morris water maze (MWM) revealed a significant decrease in learning and memory abilities at 13 days after intracerebroventricular administration of STZ, thereby providing evidence of the occurrence of DRCD in the animal model. Oral administration of LPS (1 mg/kg per day) started after cognitive impairment was observed. After 28 days of treatment, mice receiving LPS via the oral route showed significant recovery of spatial learning ability, a symptom of early dementia, while only a trend toward recovery was seen for spatial memory compared to the untreated group.

CONCLUSION:

These results, limited to MWM, suggest that oral administration of LPS is a promising therapeutic strategy for restoring decreased spatial learning ability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Aprendizaje por Laberinto / Diabetes Mellitus Experimental / Modelos Animales de Enfermedad / Disfunción Cognitiva / Aprendizaje Espacial Límite: Animals Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Aprendizaje por Laberinto / Diabetes Mellitus Experimental / Modelos Animales de Enfermedad / Disfunción Cognitiva / Aprendizaje Espacial Límite: Animals Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia