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Contribution of Radiation Sensitive Protein 51 Genotypes to Pterygium Risk in a Taiwanese Population.
Hsia, Ning-Yi; Hu, Pei-Shin; Chuang, Chin-Liang; Mong, Mei-Chin; Chen, Hung-Chih; Tsai, Chia-Wen; Wang, Yun-Chi; Chen, Jaw-Chyun; Bau, DA-Tian; Chang, Wen-Shin.
Afiliación
  • Hsia NY; Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Hu PS; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Chuang CL; Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Mong MC; Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
  • Chen HC; Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
  • Tsai CW; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
  • Wang YC; Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
  • Chen JC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
  • Bau DT; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Chang WS; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
In Vivo ; 38(5): 2197-2204, 2024.
Article en En | MEDLINE | ID: mdl-39187312
ABSTRACT
BACKGROUND/

AIM:

In current literature, there is a notable lack of studies investigating the role of radiation-sensitive protein 51 (RAD-51) in pterygium diagnosis. Nevertheless, reports indicate elevated expression levels of RAD-51 among recurrent pterygium cases compared to those with primary pterygium. However, the genomic involvement of RAD-51 has yet to be explored in any population. This study aimed to assess the contribution of RAD-51 genotypes to pterygium risk in a representative Taiwanese population. MATERIALS AND

METHODS:

RAD-51 rs1801320 genotyping was successfully conducted in a Taiwanese cohort comprising 140 pterygium cases and 280 non-pterygium controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology.

RESULTS:

The distribution of RAD-51 rs1801320 genotypes (GG, CG, and CC) in the pterygium group (70.0%, 25.7%, and 4.3%, respectively) did not significantly differ from that in the non-pterygium group (73.6%, 23.6%, and 2.8% for GG, CG, and CC genotypes, respectively; p for trend=0.6337). Carriers of the variant CG and CC RAD-51 rs1801320 genotypes exhibited 1.15- and 1.58-fold increased pterygium risk, respectively (95%CI=0.72-1.84 and 0.53-4.67, p=0.6552 and p=0.5914, respectively). In the dominant model, there appeared to be a slight association between variant genotypes CG and CC and pterygium risk (OR=1.19, 95%CI=0.76-1.87, p=0.0223). Allelic analysis revealed that the RAD-51 rs1801320 variant C allele was not significantly linked to pterygium risk (17.1% versus 14.6%, OR=1.20, 95%CI=0.82-1.78, p=0.3991).

CONCLUSION:

Variant genotypes at RAD-51 rs1801320 were firstly identified to associate with susceptibility to pterygium among Taiwanese individuals. Nonetheless, these findings warrant validation in larger and more diverse populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pterigion / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Genotipo Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pterigion / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Genotipo Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia