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Robust Synthesis of Targeting Glyco-nanoparticles for Surface Enhanced Resonance Raman Based Image-Guided Tumor Surgery.
Liu, Kunli; Ullah, A K M Atique; Juhong, Aniwat; Yang, Chia-Wei; Yao, Cheng-You; Li, Xiaoyan; Bumpers, Harvey L; Qiu, Zhen; Huang, Xuefei.
Afiliación
  • Liu K; Department of Chemistry, Michigan State University, East Lansing, MI, 48824 USA.
  • Ullah AKMA; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824 USA.
  • Juhong A; Department of Chemistry, Michigan State University, East Lansing, MI, 48824 USA.
  • Yang CW; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824 USA.
  • Yao CY; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824 USA.
  • Li X; Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, 48824 USA.
  • Bumpers HL; Department of Chemistry, Michigan State University, East Lansing, MI, 48824 USA.
  • Qiu Z; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824 USA.
  • Huang X; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824 USA.
Small Sci ; 4(5)2024 May.
Article en En | MEDLINE | ID: mdl-39185268
ABSTRACT
Surface Enhanced Resonance Raman (SERS) is a powerful optical technique, which can help enhance the sensitivity of Raman spectroscopy aided by noble metal nanoparticles (NPs). However, current SERS-NPs are often suboptimal, which can aggregate under physiological conditions with much reduced SERS enhancement. Herein, a robust one-pot method has been developed to synthesize SERS-NPs with more uniform core diameters of 50 nm, which is applicable to both non-resonant and resonant Raman dyes. The resulting SERS-NPs are colloidally stable and bright, enabling NP detection with low-femtomolar sensitivity. An algorithm has been established, which can accurately unmix multiple types of SERS-NPs enabling potential multiplex detection. Furthermore, a new liposome-based approach has been developed to install a targeting carbohydrate ligand, i.e., hyaluronan, onto the SERS-NPs bestowing significantly enhanced binding affinity to its biological receptor CD44 overexpressed on tumor cell surface. The liposomal HA-SERS-NPs enabled visualization of spontaneously developed breast cancer in mice in real time guiding complete surgical removal of the tumor, highlighting the translational potential of these new glyco-SERS-NPs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Small Sci Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Small Sci Año: 2024 Tipo del documento: Article Pais de publicación: Alemania