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Alginate oligosaccharides exert protective effects on hydrogen peroxide-induced senescence in H9C2 cardiomyocytes by regulating the redox state of cells.
Feng, Wen-Jing; Mou, Jie; Liao, Ping-Ping; Zhou, Jing; Zhang, Nan-Nan; Hu, Ting; Wang, Shan; Zhang, Shi-Yuan; Mao, Yong-Jun.
Afiliación
  • Feng WJ; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266003 Shandong China.
  • Mou J; Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, Qingdao, 266021 Shandong China.
  • Liao PP; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266003 Shandong China.
  • Zhou J; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266003 Shandong China.
  • Zhang NN; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266003 Shandong China.
  • Hu T; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266003 Shandong China.
  • Wang S; Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 China.
  • Zhang SY; Marine Biomedical Research Institute of Qingdao, Qingdao, 266073 China.
  • Mao YJ; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266003 Shandong China.
Food Sci Biotechnol ; 33(12): 2835-2844, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39184993
ABSTRACT
Aging is a known independent risk factor for several cardiovascular diseases. Here, we evaluated potential effects and possible mechanisms through which alginate oligosaccharides (AOS) affect hydrogen peroxide (H2O2)-induced senescence in H9C2 cardiomyocytes. A series of AOS molecules, including oligoM, oligoG, M-5, and G-5, were investigated. AOS significantly decreased SA-ß-gal and DAPI-stained positive cells, downregulated p53 and p21 (aging-related markers) expression, and eventually protected H9C2 cells from H2O2-induced senescence. AOS decreased reactive oxygen species and malondialdehyde production, recovered mitochondrial function, and alleviated the oxidative stress state by regulating PGC-1α and NADPH oxidase subunit expression. Furthermore, AOS treatment restored the expression of antioxidant enzymes in senescent H9C2 cells. Thus, our results show in vitro evidence that AOS alleviate senescence in H9C2 cells by regulating the redox state; thus, AOS may be an effective therapeutic agent that could protect against cardiomyocyte senescence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Sci Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Sci Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: