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Polyphenol-rich Aronia melanocarpa juice sustains eNOS activation through phosphorylation and expression via redox-sensitive pathways in endothelial cells.
Kim, Jong Hun; Choi, Min Sik; Auger, Cyril; Lee, Ki Won; Schini-Kerth, Valérie B.
Afiliación
  • Kim JH; Department of Food Science and Biotechnology and Institute for Basic Sciences, Sungshin Women's University, Seoul, 01133 Republic of Korea.
  • Choi MS; Lab of Pharmacology, College of Pharmacy, Dongduk Women's University, Seoul, 02748 Republic of Korea.
  • Auger C; INSERM UMR 1260, Regenerative Nanomedicine, University of Strasbourg, Strasbourg, France.
  • Lee KW; Department of Agricultural Biotechnology, Biomodulation Major, Seoul National University, Seoul, 08826 Republic of Korea.
  • Schini-Kerth VB; Bio-MAX Institute, Seoul National University, Seoul, 08826 Republic of Korea.
Food Sci Biotechnol ; 33(12): 2865-2875, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39184991
ABSTRACT
A sustained formation of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) is crucial to safeguard the vascular system against the development of cardiovascular diseases. This study investigated the prolonged phosphorylation and expression of eNOS induced by polyphenol-rich Aronia melanocarpa juice (AMJ), along with its underlying mechanisms. The findings revealed that AMJ triggered concentration- and time-dependent increases in eNOS phosphorylation and expression, leading to sustained NO production for 15 h. Investigations with various enzymes and inhibitors revealed that the effect of AMJ was associated with redox sensitivity, activating the PI3-kinase/Akt, JNK, and p38 MAPK pathways. These pathways led to the inactivation of transcription factors FoxO1 and FoxO3a through phosphorylation, relieving their repression on eNOS expression. Therefore, the capability of AMJ to consistently trigger prolonged eNOS phosphorylation and expression via complex redox-sensitive pathways highlights its potential for maintaining vascular health and preventing cardiovascular diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Sci Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Sci Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: