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Assessment of cytoprotective and genoprotective effects of Moringa oleifera and Tinospora cordifolia extracts in vitro.
Bagri, Preeti; Kumar, Vinod; Batra, Kanisht.
Afiliación
  • Bagri P; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125004, India.
  • Kumar V; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125004, India.
  • Batra K; Department of Animal Biotechnology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125004, India.
Toxicol Res (Camb) ; 13(4): tfae133, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39184218
ABSTRACT

Background:

Moringa oleifera and Tinospora cordifolia is extensively used as an ingredient of food and in traditional medicine for the management of a variety of diseases. Material and

methods:

The extracts of leaf of Moringa oleifera and stem of Tinospora cordifolia were assessed to examine their ability to inhibit the oxidative DNA damage (by DNA protection assay), cytoprotective and genoprotective potential (by Comet assay) in V79 cells individually and in combinations.

Result:

It was found that these extracts could significantly inhibit the OH-dependent damage of pUC18 plasmid DNA. M. oleifera extract (160 and 320 µg/mL) and Tinospora cordifolia extract (640, 1,280 and 2,560 µg/mL) individually showed higher DNA protection activity. M. oleifera (1,280 µg/mL) combined with Tinospora cordifolia (640 µg/mL) showed best cytoprotective and genoprotective activities among different concentration combinations and various concentrations of individual plants in V79 cell line against hydrogen peroxide induced cytotoxicity and genotoxicity.

Conclusion:

This study demonstrates the cytoprotective and genoprotective activity of M. oleifera and Tinospora cordifolia individually or in combination.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxicol Res (Camb) Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxicol Res (Camb) Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido