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The causal relationship between antihypertensive drugs and depression: a Mendelian randomization study of drug targets.
Yang, Zixian; Li, Jinshuai; Huang, Peichu; Li, Zhichang; He, Jianfeng; Cai, Dongchun; Lai, Yuzheng.
Afiliación
  • Yang Z; Department of Neurology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan, Guangdong, China.
  • Li J; The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
  • Huang P; Department of Neurology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan, Guangdong, China.
  • Li Z; Nanhai District Hospital of Traditional Chinese Medicine of Foshan City, Foshan, Guangdong, China.
  • He J; Nanhai District Hospital of Traditional Chinese Medicine of Foshan City, Foshan, Guangdong, China.
  • Cai D; Department of Neurology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan, Guangdong, China.
  • Lai Y; Nanhai District Hospital of Traditional Chinese Medicine of Foshan City, Foshan, Guangdong, China.
Front Endocrinol (Lausanne) ; 15: 1411343, 2024.
Article en En | MEDLINE | ID: mdl-39184138
ABSTRACT

Background:

Depression ranks as a leading contributor to the global disease burden. The potential causal relationship between the use of antihypertensive medications and depression has garnered significant interest. Despite extensive investigation, the nature of this relationship remains a subject of ongoing debate. Therefore, this study aims to evaluate the influence of antihypertensive medications on depression by conducting a Mendelian randomization study focused on drug targets.

Method:

We focused on the targets of five antihypertensive drug categories ACE Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), Calcium Channel Blockers (CCBs), Beta-Blockers (BBs), and Thiazide Diuretics (TDs). We collected single-nucleotide polymorphisms (SNPs) associated with these drug targets from genome-wide association study (GWAS) statistics, using them as proxies for the drugs. Subsequently, we conducted a Mendelian randomization (MR) analysis targeting these drugs to explore their potential impact on depression.

Results:

Our findings revealed that genetic proxies for Beta-Blockers (BBs) were associated with an elevated risk of depression (OR [95%CI] = 1.027 [1.013, 1.040], p < 0.001). Similarly, genetic proxies for Calcium Channel Blockers (CCBs) were linked to an increased risk of depression (OR [95%CI] = 1.030 [1.009, 1.051], p = 0.006). No significant associations were identified between the genetic markers of other antihypertensive medications and depression risk.

Conclusion:

The study suggests that genetic proxies associated with Beta-Blockers (BBs) and Calcium Channel Blockers (CCBs) could potentially elevate the risk of depression among patients. These findings underscore the importance of considering genetic predispositions when prescribing these medications, offering a strategic approach to preventing depression in susceptible individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Depresión / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Antihipertensivos Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Depresión / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Antihipertensivos Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza