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Specific Reversal Agents for Direct Oral Anticoagulants in Acute Stroke.
Frol, Senta; Pretnar Oblak, Janja; Sabovic, Miso; van Zwam, Wim H; Ntaios, George; Lövblad, Karl Olof; Gruber, Andreas; Kermer, Pawel.
Afiliación
  • Frol S; Department of Vascular Neurology, University Medical Center Ljubljana, Ljubljana, Slovenia.
  • Pretnar Oblak J; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Sabovic M; Department of Vascular Neurology, University Medical Center Ljubljana, Ljubljana, Slovenia.
  • van Zwam WH; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Ntaios G; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Lövblad KO; Department of Vascular Disorders, University Medical Center Ljubljana, Ljubljana, Slovenia.
  • Gruber A; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands.
  • Kermer P; CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.
Clin Appl Thromb Hemost ; 30: 10760296241279545, 2024.
Article en En | MEDLINE | ID: mdl-39183537
ABSTRACT
Direct oral anticoagulants (DOACs) changed stroke prevention and decreased the risk of ischemic and hemorrhagic complications in patients on oral anticoagulation (OAC) therapy. The numbers of patients prescribed DOACs has increased rapidly. Availability of specific reversal agents opened new avenues in the prevention and management of DOAC complications. An ideal specific reversal agent for a DOAC in acute stroke is an agent which lacks safety concerns and immediately reverses DOAC anticoagulation activity, thereby enabling effective treatment. Reversal of anticoagulant activity is mandatory in patients with acute ischemic stroke (AIS) before performing therapeutic procedures such as intravenous thrombolysis (IVT) and neurosurgery in intracranial hemorrhage (ICH) in order to improve clinical outcomes. In this manuscript we pursue an interdisciplinary approach in discussing advantages and concerns of specific reversal agents in acute stroke DOAC-treated patients in everyday clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Anticoagulantes Límite: Humans Idioma: En Revista: Clin Appl Thromb Hemost Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Anticoagulantes Límite: Humans Idioma: En Revista: Clin Appl Thromb Hemost Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Estados Unidos