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Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies.
Shrivastava, Anju; Kumar, Amit; Aggarwal, Lalit Mohan; Pradhan, Satyajit; Choudhary, Sunil; Ashish, Ashish; Kashyap, Keshav; Mishra, Shivani.
Afiliación
  • Shrivastava A; Department of Physiology, Chhattisgarh Institute of Medical Sciences, Bilaspur, India. anju.joyshrivastav@gmail.com.
  • Kumar A; Department of Anatomy, Chhattisgarh Institute of Medical Sciences, Bilaspur, India.
  • Aggarwal LM; Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
  • Pradhan S; Radiation Oncology, Mahamana Pandit Madhan Mohan Malaviya Cancer Centre, Varanasi, India.
  • Choudhary S; Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
  • Ashish A; Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
  • Kashyap K; Department of Physiology, Chhattisgarh Institute of Medical Sciences, Bilaspur, India.
  • Mishra S; Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
J Membr Biol ; 2024 Aug 25.
Article en En | MEDLINE | ID: mdl-39183198
ABSTRACT
Electrophysiology typically deals with the electrical properties of excitable cells like neurons and muscles. However, all other cells (non-excitable) also possess bioelectric membrane potentials for intracellular and extracellular communications. These membrane potentials are generated by different ions present in fluids available in and outside the cell, playing a vital role in communication and coordination between the cell and its organelles. Bioelectric membrane potential variations disturb cellular ionic homeostasis and are characteristic of many diseases, including cancers. A rapidly increasing interest has emerged in sorting out the electrophysiology of cancer cells. Compared to healthy cells, the distinct electrical properties exhibited by cancer cells offer a unique way of understanding cancer development, migration, and progression. Decoding the altered bioelectric signals influenced by fluctuating electric fields benefits understanding cancer more closely. While cancer research has predominantly focussed on genetic and molecular traits, the delicate area of electrophysiological characteristics has increasingly gained prominence. This review explores the historical exploration of electrophysiology in the context of cancer cells, shedding light on how alterations in bioelectric membrane potentials, mediated by ion channels and gap junctions, contribute to the pathophysiology of cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Membr Biol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Membr Biol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos