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Protective effect of walnut active peptide against dextran sulfate sodium-induced colitis in mice based on untargeted metabolomics.
Qi, Yuan; Wang, Xuehang; Chen, Yiming; Sheng, Lihan; Wu, Dan; Leng, Yue; Wang, Xiyan; Wang, Ji.
Afiliación
  • Qi Y; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
  • Wang X; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
  • Chen Y; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
  • Sheng L; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
  • Wu D; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
  • Leng Y; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
  • Wang X; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China.
  • Wang J; College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, PR China. Electronic address: wangji198644@163.com.
Int Immunopharmacol ; 141: 112998, 2024 Nov 15.
Article en En | MEDLINE | ID: mdl-39182265
ABSTRACT
Inflammatory bowel disease (IBD) is a chronic condition characterized by inflammation of the digestive tract, whose exact cause remains unknown, and its prevalence is on the rise. This study investigated the effects of a walnut-derived peptide LPLLR (LP-5) on intestinal inflammation and metabolism in IBD mice. Metabolomics revealed that LP-5 regulated the levels of metabolites, such as thalsimidine, fumagillin, and geniposide, and LP-5 could regulate several signaling pathways, such as protein digestion and absorption, aminoacyl-tRNA biosynthesis, and ABC transporters. Additionally, LP-5 alleviated dextran sulfate sodium (DSS)-induced colitis by modulating autophagy and inflammasome pathways. Western blotting demonstrated that LP-5 reduced the expressions of NLRP3, Caspase-1, ASC and IL-1ß, and increased the expressions of Beclin-1 and LC3-II/LC3-I, corresponding to activation of the AMPK/mTOR/ULK1 pathway. These findings suggested that LP-5 activated autophagy in vivo to suppress inflammation and modulate metabolic substances, highlighting potential implications for gut health and the development of functional foods containing LP-5.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfato de Dextran / Colitis / Juglans / Metabolómica Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfato de Dextran / Colitis / Juglans / Metabolómica Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos