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Genome-wide identification of copy number variations in wrinkled skin cases of Xiang pigs.
Liu, Xiaoli; Hu, Fenbin; Wang, Wei; Chen, Xia; Niu, Xi; Huang, Shihui; Wang, Zhou; Wang, Jiafu; Ran, Xueqin.
Afiliación
  • Liu X; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China.
  • Hu F; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China.
  • Wang W; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China.
  • Chen X; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China.
  • Niu X; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China.
  • Huang S; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China.
  • Wang Z; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China.
  • Wang J; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China. jfwang@gzu.edu.cn.
  • Ran X; Institute of Agro-Bioengineering/Key Laboratory of Plant Resource Conservative and Germplasm Innovation in Mountainous Region and Key Laboratory of Animal Genetics, College of Life Science, College of Animal Science, Guizhou University, Guiyang, 550025, Guizhou, China. xqran@gzu.edu.cn.
Sci Rep ; 14(1): 19695, 2024 08 24.
Article en En | MEDLINE | ID: mdl-39181933
ABSTRACT
Copy number variation (CNV) tends to occur in genetically enriched regions and is likely associated with a number of complex diseases such as skin aging. In this study, we investigated the genome-wide CNVs in 20 wrinkled skin cases (WSC) of Xiang pigs and 63 controls, and identified 7893 copy number variable regions (CNVRs). We estimated the F-statistic (Fst) at each locus and identified that 93 case-controls stratified CNVRs (Fst > = 0.15) overlapped with 87 known genes. Functional enrichment analysis showed that most of these genes were predominantly enriched in pathways and terms related to the extracellular matrix. Finally, we found that some CNVs were predicted to have high effects on genes such as VCAN, TIMP1 and FOXO1 through transcriptional amplification, transcript ablation and so on. Most of the genes overlapped with those CNVRs have been reported to be related to aging in human or animals. The copy numbers presented the positive correlations with the transcript level of the genes in skins between the cases and controls. Our results suggested that those 22 CNVRs, including 19 CNV losses and 3 CNV gains, were putatively associated with the skin wrinkle of Xiang pigs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel / Variaciones en el Número de Copia de ADN Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel / Variaciones en el Número de Copia de ADN Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido