Cytosine methylation flags mitochondrial RNA for degradation.

Recazens, Emeline; Jourdain, Alexis A

Recazens, Emeline; Jourdain, Alexis A.

Afiliación

Recazens E; Department of Immunobiology, University of Lausanne, 1066 Epalinges, Switzerland.
Jourdain AA; Department of Immunobiology, University of Lausanne, 1066 Epalinges, Switzerland. Electronic address: alexis.jourdain@unil.ch.

Trends Biochem Sci ; 2024 Aug 23.

Article en En | MEDLINE | ID: mdl-39181838

ABSTRACT

ABSTRACT

Mitochondrial double-stranded RNA (dsRNA) can form spontaneously in mitochondria, blocking mitochondrial gene expression and triggering an immune response. A recent study by Kim, Tan, et al. identified a safeguard mechanism in which NOP2/Sun RNA methyltransferase 4 (NSUN4)-mediated RNA methylation (m5C) recruits the RNA degradation machinery to prevent dsRNA formation.

Palabras clave

5-methylcytosine; RNA degradation; dsRNA; immunity; mitochondrial RNA; nucleic acid sensing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Trends Biochem Sci Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

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